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Nipple sensitivity after prophylactic nipple-sparing mastectomy compared to healthy BRCA1/2 gene mutation carriers.

The aim of this study is to objectify nipple-areola complex sensitivity in women who underwent unilateral or bilateral prophylactic NSM in Erasmus MC-Daniel den Hoed Cancer Center and their satisfaction with this operation, compared to healthy women…

The efficacy of a physical intervention study for the improvement of the rest-activity rhythm and working memory in persons with Down*s syndrome suffering from Alzheimer*s disease. A pilot-study

The primary objective of the study is to examine the feasibility of measurements, program design and implementation adherence of a cardiovascular exercise program in persons with Down*s syndrome suffering from Alzheimer*s disease. Secondary…

Which is the most cost-efficient paradigm of early screening for fetal congenital abnormalities?

This study is designed to identify the best performing screening strategy within the options currently available in the Dutch prenatal screening program by investigating whether postponement of the dating scan to 12-13 weeks and NIPT thereafter…

Long-term safety of preimplantation genetic diagnosis
Follow-up of 5 and 8-year old children born after PGD

Long-term follow-up of children who have been born after PGD in The Netherlands. The primary aim is to assess the safety of PGD with regard to the health and development of the children.

Pharmacokinetic interactions between ivacaftor and cytochrome P450 3A4 inhibitors in cystic fibrosis patients and healthy controls

The primary objective of this study is to evaluate the effect of multiple doses of azithromycin, clarithromycin and ritonavir on the pharmacokinetics, safety and tolerability of a single oral 150 mg dose of ivacaftor in healthy controls and in…