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Prognosis of Idiopathic CD4 Lymphocytopenia in children

- The primary research objective is to estimate the prognosis of children affected by ICL. - A secondary research objective is to explore the heredity of ICL between first degree family members.

Genetics of Autoimmune Diseases

The research strives for a large group of homogeneous AID patients, so that a powerful association study can be performed to detect genetic risk factors. These factors can be shared by several AIZ, or be specific is for a single AID. The aim of this…

B-cell differentiation defects and clinical complications in antibody deficiency syndromes with a focus on Common Variable Immunodeficiency

To detect B-cell differentiation and maturation defects in patients with antibody deficiency syndromes of unknown origin (CVID, SAD), which are predictive for clinical complicationsTo detect and sequence candidate genes in subgroups of patients with…

Recurrent respiratory tract infections (RRTI) in the elderly: from phenotypic and immunological characterizaton to a mechanistic unravelling of a potential primary immunodeficiency (PID).

The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…

Impact of Alemtuzumab exposure on immune reconstitution, autoimmunity, risk of infection, chimerism and Graft-versus-Host Disease in children with non-malignant diseases undergoing allogeneic stem cell transplantation. ARTIC International Multicenter Observational Study.

Primary objectiveTo evaluate current clinical practice and develop a population based Campath® (Alemtuzumab) pharmacokinetics model for predicting total Alemtuzumab exposure after i.v. administration before allogeneic stem cell transplantation in…

Understanding colchicine resistance in Familial Mediterranean Fever; exploring pathophysiological mechanisms and therapeutic options

The primary objective is to identify what causes colchicine resistance in FMF. Additionally, we will try to identify potential interventions to overcome resistance