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Subjective cognitive impairment and mild cognitive impairment: a sign of incipient Alzheimer*s disease?
* A longitudinal study of functional and structural brain changes in healthy older adults with and without cognitive complaints.

1. To investigate the differences between healthy older adults with and without cognitive complaints (SCI) and MCI patients in: a) resting state functional connectivity; b) brain structure; and c) cognitive function. 2. To investigate longitudinal…

Dysphagia in Neuromuscular diseases, pathophysiology and treatment implications

The objective is to describe the nature and underlying (neuromuscular en biomechanical) factors of dysphagia in different neuromuscular diseases in relation to different consistencies of food. Identifying the contributing factors are starting points…

MRI of the sacral plexus and sacral nerve roots in children with neurogenous bladder dysfunction with sacral or spinal anomalies

Gain insight in the anatomy and organisation of the sacral plexus in children with NB and congenital spinal or sacral anomalies. Possible findings can be compared with the results of the healthy subjects, in order to be able to relate findings to…

Dysphagia in children with congenital myopathy, underlying mechanisms and advices for assessment and treatment

Objective 1To describe the course and underlying mechanisms of dysphagia in children with congenital myopathy (from 6 months to 12 years)Objective 2To formulate recommendations for early detection, diagnostic assessment , treatment and advices for…

Muscle properties in children with cerebral palsy undergoing orthopaedic surgical intervention to improve gait

The aims of the proposed study are (1) to test the reliability of knee moment-angle measurements, (2) to obtain insight how muscle and tendon characteristics in children with CP contribute to the limitations in range of motion (ROM) of the knee and…

MR imaging of the spinal cord in patients with spinal muscular atrophy (SMA) and healthy controls

To investigate the potential value of magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) on a 3 Tesla MRI system to visualize the spinal cord in SMA patients and to investigate motor connectivity in vivo in patients with SMA.

Biomarkers in Intermediate Allele Carriers, Adult-, and Early-onset Huntington*s Disease Patients.

The primary objective:To identify fluid and radiological biomarkers, in IA carriers, AHD patients, and EoHD patients, that can be linked to clinical outcome measures. We aim to link longitudinal changes in these biomarkers to disease progression.…

Quantifying paretic upper limb impairment in stroke and cerebral palsy

To develop a feasible assessment protocol to quantify the impaired upper extremity function in terms of muscle weakness, spasticity, synergy and viscoelastic properties around the elbow.To evaluate the reliability (test-retest, measurement error)…

10-year extension study: prospective systematic follow-up for X-linked adrenoleukodystrophy.

The primary objective of the study is to develop new sensitive and quantitative outcome measures for clinical trials in ALD. The secondary objective is to identify biomarkers to stratify patients based on disease progression rate.

Follow-up study of amyloid detection in HCHWA-D patients, a monogenetic variant of cerebral amyloid angiopathy

The general aim of this study is to investigate if the early markers seen in presymptomatic patients predict progression of the disease. Furthermore, we can study if the disease markers we found in the mutation carriers predict disease severity.