34 results
To collect data regarding the prevalence of:I) - osteoporosis in SCI patients and the relation to characteristics of SCI. - fractures in SCI patients and the relation to characteristics of SCI. - active treatment of osteoporosis in SCI patients.II…
Protocol 1: To determine whether pituitary dysfunction is present at intermediate duration of follow-up after traumatic brain injuryProtocol 2: To determine whether injury to brain tissue that explains traumatic brain injury-induced pituitary…
Primary objective:1. To assess the effect of SXB treatment on cold-induced BAT volume and activity in narcolepsy type 1 patients.Secondary objectives:1. To assess the effect of SXB treatment on thermoneutral BAT volume and fat fraction, lipoprotein…
Primary objective:1. To assess the effect of 4 weeks SXB treatment on basal and cold-induced WAT lipolysis (assessed by levels of circulating free fatty acids) in narcolepsy type 1 patients. Secondary objectives:1. To assess the effects of 4 weeks…
The primary objective of this study is to determine the effect of transsphenoidal adenomectomy on parameters of macular ganglion cell thickness and the PIPR in patients with optic chiasm compression. The main secondary objective is to assess the…
The aim of this study is to assess whether withdrawing GH treatment after mid-puberty in adolescents with idiopathic isolated GH deficiency, who showed a normal result in a GH stimulation test at retesting, is as effective as continuing GH until…
To compare free testosterone levels between male CCH patients and healthy controls Secondary Objectives: To compare differences in androstenedione, DHEA, DHT and 11oxC19 level, testosterone/estrogen ratio, activin level, inhibin level and morning…
Primary questionAre changes in vigilance in type 1 and 2 narcolepsy, idiopathic hypersomnia and epilepsy with only nocturnal seizures reflected in differences in the responsiveness of the pupils to light as measured by pupillometry (PIPR) versus…
Our main objective is to assess the difference in PIPR after a blue-light stimulus between hypopituitarism patients with and without a history of CC. Secondary objectives include differences in subjective and objective sleep quality, sleep-wake…
To assess the diagnostic accuracy of total and free IGF-1 concentrations by comparing it to the gold standard for detection of growth hormone deficiency in adults, i.e. the insulin tolerance test, in subgroups of patients at risk for growth hormone…
To assess the efficacy and safety of LCI699 in CD patients
The overall aims of this project are 1) to improve our understanding of CS, in particular the spectra and time course of impaired well-being, fatigue and cognition, 2) to study the mechanisms behind the apparently long-term negative consequences on…
The role of inflammation in the pathogenesis of cardiovascular morbidity in patients with acromegaly
Primary Objective: To examine comprehensively the role of inflammation in the pathogenesis of CV complications in acromegaly. This will be done by exploring the inflammatory and metabolic profiles of patients with acromegaly and correlating these…
Primary Objectives: - Assess the feasibility and clinical value of 7T MR to provide a more detailed anatomic description of the anterior visual pathway in NFMA patients compared to conventional MRI. - Assess the feasibility of high-field MRI to…