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Genome-wide sequencing for the identification of potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma in children

To detect potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma.

The retro-orbital fibrobast: a key player in Graves* opthalmopathy and a target for therapy.

Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.

Coagulation and fibrinolysis in patients with resistance to thyroid hormone due to a thyroid hormone receptor β-gene mutation

To investigate the effect of resistance to thyroid hormone (RTH) due to a TRβ mutation on coagulation and fibrinolysis

Hypo vWf: hypothyroidism and Von Willebrand factor.

This observational cohort study is designed to evaluate the prevalence of acquired von Willebrand*s syndrome in patients with a new diagnosis of overt hypothyroidism.

Markers of airway inflammation in auto-immune hyperthyroidism; the interaction between thyroid and airways

Hypothesis:In auto-immune hyperthyroidism there is an increase of (eosinophil)airwayinflammation compared to healthy test subjects.Objective:testing our hypothesis by answering the following questions:1. What is the difference in NO in exhaled air…

Effect of treatment with levothyroxine in a patient with thyroid hormone receptor *1 deficiency

Objective: The primary objective of the study is to determine the effect of standard treatment with levothyroxine in TR*1 deficiency on:- Neutrophil and macrophage function- Erythropoiesis- Thyroid hormone target gene expression- Plasma metabolome

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek:
Thyroid function, in children and adults, after treatment for childhood cancer

To assess the prevalence of hypothyroidism and hyperthyroidism in the entire cohort of childhood cancer survivors and the therapy related risk factors. Specifically:Part I: 1. To systematically review existing studies on the association between…