16 results
Verification of functional tests with the LoRRca, a next generation ektacytometer, on red blood cells of healthy individuals with or without comorbidities/risk factors.
To perform a human study demonstrating a detailed analysis of electrical and mechanical activation under different cardiac pacing conditions and to describe the accompanying hemodynamic response.Objectives:To demonstrate non-invasive mapping…
The main objective of the study is to document cardiovascular dysfunction found in rheumatoid arthritis and gout patients using cardiac imaging techniques echocardiography and cardiac MRI.
To gain a better insight into the genetic factors that play a role in the etiology of the thoracic aortic aneurysm with the following specific aims:1. Study of specific geneitc factos that play a role in the pathogenesis of both syndromic and non-…
Primary Objective: To assess whether ageing across body systems is accelerated by sub-optimal early life circumstances.Secondary Objective: To asses underlying mechanisms of the potential association between sub-optimal early life circumstances and…
To observe the possible relationship between central, conventional hemodynamic parameters with relatively new peripheral, regional perfusion parameters in two versions of a model with controlled vasocontriction (cooling) - vasodilation (heating)
To evaluate whether an increase in inflammatory- and coagulation parameters can be found in healthy volunteers with elevated hsCRP levels compared to age and BMI matched healthy volunteers with normal hsCRP levels
Prevalence of cardiovascular disease and their risk factors in patients with ankylosing spondylitis.
This research must answer the following questions: (1) what is the prevalence of CVD in AS patients?(2) what is the incidence of CVD in patients with AS? (3) which risk factors contribute to the development of CVD in AS? (4) to which extent AS…
Using epigenetic, transcriptional, metabolomic and proteomic approaches in cardiac and skeletal muscle tissue, we want to reveal distinct biological pathways affected in ACM, DCM and PLN r14del cardiomyopathy.
To determine the occurrence and natural history of (subclinical) cardiac abnormalities during hospital admission for COVID-19 and the possible cardiovascular complications short-tem (6 months) and long-term (1,2,5,10 years) post-admission.
To identify host risk factors through genetic and immunological screening that may be associated with the development of cardiac SAEs following CHMI. Identification of such factors may on the one hand allow at-risk individuals to be screened out…
Our goal is to build up a deep phenotyped HFpEF cohort, to be able to select the right patients for different HFpEF studies with the final goal of improving the understanding of the pathophysiology of HFpEF. The HFpEF cohort will allow us to…
Objective: The aim of the present study is to study the effect of increased adrenaline levels on the inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by administering exogenous adrenaline. Secondary aims consist of…
Primary objectives: - To examine how environmental exposures influence the prevalence, 5-year incidence and progression of cardiometabolic and chronic respiratory disease in the general population. - To determine the mediation effect of lifestyle…
Primary Objective(s):1. To study the presence and extend of exercise intolerance in male, female FD patients with classical FD and men with non-classical FD, in different stages of the disease.2. To determine the aetiology of exercise intolerance in…
The main objective of this study is to obtain valuable biomarkers that are useful in the prediction of the presence of (subtypes of PH) and/or treatment responses. Nucleic acid expression patterns will be determined in plasma and peripheral blood.…