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Genes and gene-function in bicuspid aortic valves

The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…

Endothelial Colony Forming Cells, Endothelial Progenitor Cells and Bicuspid Aortic Valves: in vitro culture of peripheral blood cells to study biomarkers and pathogenesis in BAV?

The main objective of this study is to find biomarkers for the prognosis of the BAV patients by investigating ECFC and EPC functioning, and to gain knowledge on physiological and pathological processes in patients by investigating molecular…

Myeloid cell reprogramming in aortic valve stenosis

To test the hypothesis that patients with AoS have a higher prevalence of CHIP driving mutations compared to control subjects. Secondary objectives are to perform extensive phenotyping of circulating monocytes.

Pulmonary artERial hypertenSion: bonE morPHOgeNEtic protein signaling out of control (PERSEPHONE)

Assess BMP10 secretion in patients with pulmonary arterial hypertension and its effect on right ventricular adaptation to pressure overload.