41 results
The primary objective is to assess the 18-month incidence of inappropriate shocks in subjects implanted with the EMBLEM Subcutaneous Implantable Defibrillator (S-ICD) programmed with zone cutoffs at 200 bpm and 250 bpm and:- an indication for…
Primary objectiveTo assess the outcome of NOAC associated bleeds and emergency invasive surgery or procedures. Secondary objectives1) To describe the treatment of patients presenting with NOAC associated bleeding2) To evaluate the current…
This study will investigate the effects of renal nerve stimulation before and after percutaneous transluminal renal denervation on cardiac excitable properties including induction of ventricular tachy-arrhythmias before and after renal denervation…
The main objective of this study is to obtain more insight in the (human) mechanism underlying BVR by assessing the correlation between response of BVR to preload variation in study subjects (with and) without electrical remodelling (based on…
Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
Optimise post PVI management using ambulant continuous patient-driven eHealth monitoring after catheter ablation in the treatment of atrial fibrillation.Primary Objective:1) Determine the effect of eHealth on clinical management, outcomes and…
Primary Objective: to compare the atrial contractility by means of echocardiography between patients receiving flecainide and vernakalant i.v. after conversion to sinus rhythmSecondary Objective(s): 2a. To compare the conversion rate of AF between…
1) To improve our understanding of the underlying pro-arrhythmic substrate and electrophysiologic mechanisms of VA in NICM, and to develop individualized treatment for VA based on the identified substrate. 2) To improve risk stratification for VA…
1) To evaluate the feasibility and the acute effect of intra-operative cryoablation of the slow conducting anatomical isthmuses (endpoint bidirectional conduction block) and on the re-inducibility of monomorphic isthmus dependent VT. 2) To study the…
Primary Objectives: 1. To assess the values of ARI and APDR in NICM patients. 2. To assess the three-dimensional heterogeneity of ARI and APDR in NICM patients.3. To compare 1. and 2. with the same data collected from non-NICM patients.4. To…
Is sympathetic innervation and perfusion disturbed in patients with chronic kidney disease and will is change after HD?
- To investigate the cause of the symptoms patients with a vagus nerve stimulator experience during exercise.- To investigate whether there are changes in EEG during stimulation.
Objectives: 1/. To study the proarrhythmic effects of intracellular Ca2+ signaling alterations in AF.2/. To study the nuclear Ca2+ signaling in AF.3/. To study the Ca2+-dependent pathways activated in AF and the consequences of the inactivation of…
To construct an optimal diagnostic protocol enabling general practitioners to distinguish between dizzy elderly patients who need treatment, dizzy elderly patients who need further diagnostics and dizzy elderly patients who need no further…
The objective of the study is to investigate the performance of the arrhythmia detection algorithms that will be built into the Reveal XT® insertable loop recorder. The Reveal XT® detection algorithms are designed to detect atrial tachyarrhythmias,…
To investigate if an AF dependent dysbalance of the physiologically most important pro- and antithrombotic proteins, TF and TM respectively, exists in the atrial appendages.
-To characterise total mortality risk in a prospective patient cohort of ICD candidates newly implanted for primary prophylaxis of malignant ventricular arrhythmias, compared to a non-randomised control group not implanted for primary prophylaxis.-…
To identify genetic modifiers by means of whole-exome (or targeted-genome) sequencing of members of this founder population. Secondarily, to establish a comprehensive genotype-phenotype correlation, focussing on clinical and cellular…
We aim to to record heart rate patterns during seizures with miniaturized wearable EKG-monitors in a large cohort of DS