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influence of preload on repolarization (iPORT)

The main objective of this study is to obtain more insight in the (human) mechanism underlying BVR by assessing the correlation between response of BVR to preload variation in study subjects (with and) without electrical remodelling (based on…

Searching for Explanations for Cryptogenic Stroke in the
Young: Revealing the Etiology, Triggers, and Outcome

Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…

Substrate and mechanisms of ventricular arrhythmia in non-ischemic cardiomyopathy

1) To improve our understanding of the underlying pro-arrhythmic substrate and electrophysiologic mechanisms of VA in NICM, and to develop individualized treatment for VA based on the identified substrate. 2) To improve risk stratification for VA…

Ablation of slow conducting anatomical isthmuses in patients with repaired Tetralogy of Fallot, who undergo reoperation for pulmonary valve replacement and who are at risk for isthmus related ventricular arrhythmias.

1) To evaluate the feasibility and the acute effect of intra-operative cryoablation of the slow conducting anatomical isthmuses (endpoint bidirectional conduction block) and on the re-inducibility of monomorphic isthmus dependent VT. 2) To study the…

Heterogeneity of Activation Recovery Interval and Restitution in Non-Ischemic Cardiomyopathy and its relation to Ventricular Arrhythmias

Primary Objectives: 1. To assess the values of ARI and APDR in NICM patients. 2. To assess the three-dimensional heterogeneity of ARI and APDR in NICM patients.3. To compare 1. and 2. with the same data collected from non-NICM patients.4. To…

Hypercoagulable Atrial Appendages in atrial fibrillation (AF): a cross sectional pilot study

To investigate if an AF dependent dysbalance of the physiologically most important pro- and antithrombotic proteins, TF and TM respectively, exists in the atrial appendages.

Worm Study: Identification of Modifier Genes in a Unique Founder Population with Sudden Cardiac Death

To identify genetic modifiers by means of whole-exome (or targeted-genome) sequencing of members of this founder population. Secondarily, to establish a comprehensive genotype-phenotype correlation, focussing on clinical and cellular…

Cardiac arrhythmias in Dravet syndrome

We aim to to record heart rate patterns during seizures with miniaturized wearable EKG-monitors in a large cohort of DS

Quantifying Electropathology in Adult Patients with Congenital Interatrial Communications
an endocardial mapping study

to quantify atrial electropathology of the endocardium in adult patients with CHD and to correlate clinical characteristics, atrial volume, electropathology, atrial ectopy and features of pre- and post-procedural atrial fibrillation.

AmStErdam Cohort StUdy of Patients at Risk for VEntricular Arrhythmias

The aim of this study is to investigate to what extent biomarkers are related to the development of ventricular arrhythmias, in order to improve the indication for ICD therapy.

A CELL-based platform to study the role of the micRotubule network in pediatric inHeritable arrhYTHMia patients and Improve the effiCacy of drug treatment

Primary objectives: The first aim is to examine the role of microtubule network in electrical conduction, protein localization and function in induced cardiomyocytes from pediatric BrS patients, life threatening ventricular arrhythmia patients and…

Influence of the Menstrual Cycle on the QT interval in females with Long QT-syndrome

Evaluate the effect of the menstrual cycle on QTc among females with LQT1 or LQT2 and to put our previous findings in a broader perspective by including controls groups and older females.