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Reducing Micro Vascular dysfunction In revascularized STEMI patients by off-target properties of ticagrelor

To determine if ticagrelor at treatment steady state will be associated to an improved microvascular function as compared to prasugrel in revascularized STEMI patients.

A RANDOMIZED, PARTIALLY-BLINDED, MULTI-CENTER, ACTIVE-CONTROLLED, DOSE
RANGING STUDY ASSESSING THE SAFETY, EFFICACY, AND PHARMACODYNAMICS OF THE
REG1 ANTICOAGULATION SYSTEM COMPARED TO UNFRACTIONATED HEPARIN OR LOW
MOLECULAR HEPARIN IN SUBJECTS WITH ACUTE CORONARY SYNDROME

To evaluate the safety and efficacy of the REG1 Anticoagulation System in Acute Coronary Syndrome patients undergoing cardiac catheterization by determination of the clinically acceptable dose range of RB007, which can be used to reliably reverse…

Prospective, multi-center, randomized, heparin-controlled dose-finding trial to evaluate the efficacy and safety of rivaroxaban, a direct factor Xa inhibitor, on the background of standard dual antiplatelet therapy to support elective percutaneous coronary intervention (X-Plorer).

The aim of this study is to assess whether rivaroxaban, as compared to UFH, on the background of standard dual antiplatelet therapy (DAPT), can effectively suppress thrombosis, and related adverse ischemic events, upon balloon inflation and stent…

Het Siemens INNOVANCE* PFA P2Y Test Cartridge Project

The aim of the present study is a performance evaluation of INNOVANCE® PFA P2Y. The first objective is the determination of a reference interval for the Intended Use Population (patients eligible for Clopidogrel therapy). This will be done by…

Potential of patient derived vascular cells for usage in vascular tissue engineering

Primary Objective: a) Do EC/SMC from patients with cardiovascular disease and renal failure have inferior reproductive capacity compared to cells from control donors?Secondary Objectives: a) What is the interindividual variation of cultured…

Can HDL Infusions Significantly Quicken Atherosclerosis Regression?
A phase II, Multi-center, double-blind, ascending dose, placebo-controlled, dose-finding trial of CER-001 or placebo in subjects with acute coronary syndrome.

To assess the impact of six IV infusions of 3, 6, or 12 mg/kg of CER-001 or placebo, given at weekly intervals, on atherosclerotic plaque volume, as measured by coronary IVUS.

Pressure-controlled Intermittent Coronary Sinus Occlusion in Patients with ST-segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention:
Safety and Feasibility Study

Primary Objective:Proof of concept study designed to document the safety and feasibility of adjuvant treatment with the PICSO Impulse system in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) treated with primary PCI…

The effect of red blood cell transfusion on the microcirculation after cardiac surgery.

The aim of this clinical study is to determine, what the effect of RBC transfusion is on the microcirculation after cardiac surgery in the ICU, as compare to asanguineous colloid (Gelofusine®) infusion.

Coronary versus Intravenous abCiximab administration during Emergency Reperfusion Of ST-segment elevation myocardial infarction - the CICERO trial

To investigate whether IC administration of abciximab during primary PCI is superior to IV administration in improving myocardial perfusion in patients with STEMI.

Het Siemens INNOVANCE* PFA P2Y Test Cartridge Project

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Aspirin sensitivity in diabetes mellitus;
the role of glycaemic control and dosing

The main objective of this study is to determine the role of glycaemic control in diabetes mellitus in the occurrence of acetylsalicylic acid resistance, the secondary objective is to determine the effect of increased dosing on acetylsalicylic acid…

Double-Blind follow-on study of Pitavastatine (4mg)versus atorvastatine (20 mg and 40 mg), with a single extension of treatment in patients with type II Diabetes Mellitus and Combined Dyslipidemia

To assess long-term safety and tolerability of pitavastatin 4 mg once daily (QD)To assess the efficacy of pitavastatin (4 mg QD) and simvastatin (40 mg and 80 mg QD) in terms of LDL-C target attainment (European Atherosclerosis Society [EAS] and…

Double-blind follow-on study of Pitavastatin (4 mg) versus Simvastatin (40 mg and 80 mg), with a single-blind extension of treatment, in patients with Primary Hypercholesterolemia or Combined Dyslipidemia and 2 or more risk factors for Coronary Heart Disease

To assess long term safety and toleralibility of Pitavastatin 4 mg QD. To assess the efficacy of Pitavastatin (4 mg) and simvastatin (40 mg and 80 mg QD) in terms of LDL-C target attainment (EAS and NCEP) following 16 weeks and 44 weeks of treatment…

Does ticagrelor modulate the inflammatory respons to human endotoxemia?

To study whether ticagrelor, added to acetylsalicylic acid, modulates the inflammatory response to the administration of lipopolysaccharide (LPS) in humans in vivo.

PulseCath Mechanical Support Evaluation

This is a mechanistic exploratory study. The objective of this study is to determine the effects of PulseCath® iVAC2L on ventricular loading conditions and assess impact on specific load and flow dependent humoral factors as well as cardiac enzymes…

SELECTIVE INTRACORONARY HYPOTHERMIA IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION TO REDUCE INFARCT SIZE

To evaluate the effectiveness of selective intracoronary hypothermia in patients with anterior wall ST-elevation myocardial infarction to limit reperfusion injury and to limit infarct size.

Patients with Angina and MicrOvaScular DysfunctIon treaTed with cardiac non-InVasivE SHOCK wave therapy, a first in man pioneering trial
-POSITIVE SHOCK-

Problem definition and objectivesThe microcirculation can only be measured by coronary blood flow parameters during catheterization. Patients with MVD will be offered an unique first in man non-invasive therapy namely: external low intensity shock…

Body Weight Adjusted Clopidogrel treatment in patients with CORonary artery Disease (BW-ACCORD)

This study has been transitioned to CTIS with ID 2024-518890-33-00 check the CTIS register for the current data. To determine if clopidogrel treatment can be optimized in patients with a low or high BW/BMI compared to patients with a normal BW by…

Specifying the anti-inflammatory effects of ziltivekimab with diverse imaging modalities and in-depth cellular phenotyping

This study has been transitioned to CTIS with ID 2024-515893-29-01 check the CTIS register for the current data. To study whether ziltivekimab therapy reduces arterial wall inflammation as assessed by imaging, and reduces the systemic inflammatory…

European trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction

Compare median two-year clinical outcome after OCT guided vs. standard guided revascularization of patients requiring complex bifurcation treatment.