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Acceptability and feasibility of exercise therapy in an aquatic environment for patients after burn injury

To investigate the acceptability and feasibility of exercise therapy in an aquatic environment by patients after burn injury.

Differential modulation of dendritic cell (DC) maturation and associated signal transduction as the pivotal events for leprosy spectral pathology

Overall aim: To study the influence of M.leprae antigens on differentiation and maturation of DCs and to identify M.leprae antigens, receptors on antigen presenting cells and signaling pathways which play a role in leprosy pathology. Main objective…

A pilot study to investigate whether fatigue is a side effect of etanercept in patients with moderate to severe psoriasis

To investigate whether fatigue is a side effect of etanercept.

Long-term stability and survival rates of a novel Oticon Medical bone conduction device implant

The overall aim of the study is to investigate the Ponto wide implant considering; initial implant stability, stability over time, skin reaction and long term success when loaded at 3 weeks post surgery. Patients* quality of life improvements…

A study of biological, immunological and physiological parameters describing skin irritation induced by a physical stimulus in healthy male volunteers

Primary objectivesTo study the relation between the physiological, microbiological and immunological status of the skin and the response to an external stimulus; to assess:• the relations between microbiome and/or immunology and the skin type;• the…

Differences in unaffected skin of patients with hidradenitis suppurativa compared with healthy controls.

To compare the microbiome, histology, immunohistochemistry and gene expression profile of healthy skin from the axillae or groin of 10 healthy volunteers with uninvolved axilla or groin skin from age, gender, body mass index, and smoking status…

A Phase 0, single-center study to characterize the response of a UV-B skin challenge on the skin of healthy volunteers and cutaneous lupus erythematosus (CLE) patients.

Primary Objectives- To characterize the dermal immune response of healthy volunteers following a UV-B skin challenge- To characterize the dermal immune response of CLE patients following a UV-B skin challenge on non-lesional skin- To evaluate the…

An exploratory, multi-centre, two-part study to describe chronic induced urticaria characteristics and explore novel biomarkers with a multimodal patient profiling approach by comparing CIndU patients to chronic spontaneous urticaria patients and healthy volunteers

The objective of this study is to deep phenotype CIndU (subtype SD and ColdU) and detect novel biomarkers for diagnosis and treatment response as well as establish methodologies for (non-) invasive monitoring of treatment effects in chronic…

A prospective, multi-center, observational biomarker real-world evidence study for in-depth profiling of patients with chronic immune-mediated inflammatory skin diseases in daily practice

The objective of the Next Generation ImmunoDermatology project (funding NWO, program NWA-ORC) is to deep profile immune-mediated inflammatory diseases for the identification of biomarkers that can identify different disease endotypes that can…

An exploratory, non-interventional, single-center study to characterize a set of immune cells in a range of dermatologic diseases

Primary To evaluate the prevalence of specific immune cell subsets in a range of IMID dermatologic disease patients, both between diseases and compared to healthy volunteers  Secondary To evaluate the variability in specific immune cell…