187 results
The primary objective of this study is to determine the anti-inflammatory potential of mechanical auricular Vagus nerve stimulation in healthy humans.
The comparison of numbers and suppressive function of Treg in a population of severe psoriatic patients in peripheral blood by flowcytometry and the assessment of a Th17 (e.g. IL-17) cytokine profile from the supernatants. Furthermore, the relation…
First, to develop a diagnostic method for non-infectious uveitis in childhood. Second, to analyze iris and ciliary body tissues of children with uveitis on the presents of inflammatory infiltrate. The results of this study will contribute in the…
In this pilot study the effects of exercise on muscle energetics in the proximal muscle groups of the legs with patients with Juvenile Dermatomyositis will be cross-sectional studied. This will be done with an exercise test using a recumbent bicycle…
This pilot study will be performed to investigate whether the cantharidin-induced blister method is a useful alternative for the vacuum blister method in patients with acute or chronic CRPS.Replacement of the vacuum blister method by the filter disc…
This study observes the immune system of children and adults who have been without a thymus for 3 to 30 years. Our objective is to study the role of the thymus in the developing immune system. In addition this study will give insight in the long…
To detect B-cell differentiation and maturation defects in patients with antibody deficiency syndromes of unknown origin (CVID, SAD), which are predictive for clinical complicationsTo detect and sequence candidate genes in subgroups of patients with…
The primary goal of this study is to evaluate the efficacy and safety of influenza, pneumococcal and hepatitis B vaccination in patients with rheumatic autoimmune diseases treated with immunosuppressive therapy compared to healthy controls. The…
PrimaryTo assess the prevalence of anti-efalizumab positivity in two sub-populations of psoriatic subjects trated with Raptiva® in the framework of the CLEARESTTM study:- Subjects developing adverse events (AEs) corresponding to pre-specified newly…
In this pilot study patients treated with a single course of rituximab or treated with multiple courses of rituximab, matched RA controls treated with methotrexate and healthy controls will be included in order to answer the following questions:1.…
researchs aims- to assess the frequency of auto-immune disease in patients with dystrophia myotonica type II compared to patients with dystrophia myotonica type I- to assess the frequency of auto-antibody formation in patients with dystrophia…
We hypothesise that EC dysfunction is present in SLE and WG patients compared to controls. In summary, our hypothesis leads to the following questions:1. Is EC dysfunction, measured by SAE, present in SLE patients?2. Is EC dysfunction related to EC…
Primary: to compare inflammatory activity in atherosclerotic lesions between patients with active RA and controls, and to address the potential of anti-inflammatory therapy to reduce inflammatory atherosclerosis in RA patients.Secondary: 1] to…
Our aims are to analyse whether there is a specific HLA allele or allelic combination associated with susceptibility to LGI1 encephalitis, and to perform a pilot study with HLA subtyping in patients with encephalitis due to antibodies to Caspr2,…
The purpose of the study is to investigate to what extent LNP1955 is tolerated and safe.It will also be investigated how quickly and to what extent LNP1955 is absorbed and eliminated from the body (this is called pharmacokinetics). Further, the…
The objective of this study is to investigate of inflammatory tissues of patients with SS contain autoreactive B cell expansions that are differently activated compared to other B cell expansions in patients with SS and in persons with salivary…
To determine the vaginal microbiota composition during preeclampsia
The aim of the study is to evaluate the efficacy of sensor augmented pump (SAP) therapy with MiniMed* 640G and SmartGuard* in preventing hypoglycemic events in comparison with continuous subcutaneous insulin infusion (CSII) therapy in type 1…
The objective of this study is to investigate the role of inflammatory mediators (circulating platelet activity levels, MP numbers, and levels of plasma/urinary mtDNA) to the occurrence and severity of acute rejection and renal outcome.
To collect demographic, clinical, therapeutic, microbiotic and imaging data in patients with JIA, to build a repository, to find novel biomarkers and to construct computerized models to predict the prognosis in children with JIA af the time of…