187 results
Primary objectives:1. To determine the gene frequencies of HLA-A, B, C, DR and DQ in patients with autoimmune encephalitis and compare this to the general Dutch population. 2. To determine genetic risk factors for the development of autoimmune…
To evaluate the presence and extent of myocardial inflammation, fibrosis and myocardial perfusion in SSc patients with either PH-LHD or PAHPAH and/or PH-LHD, in comparison to patients with idiopathic pulmonary arterial hypertension (IPAH) by means…
Target to B! - Towards patient-tailored immunotherapy to effectively treat B-cell associated disease
To characterize the antibody and the immune cell compartment in B-cell-related disease in different states of disease activity. Study objectives fall within two main groups: 1) to compare antibodies to self or non-self-antigens before and after…
Primary• To evaluate the effect of ravulizumab on adjudicated On-Trial Relapses in adult patients with NMOSDSecondary• To evaluate the safety of ravulizumab in adult patients with NMOSD• To evaluate the effect of ravulizumab on adjudicated…
Our hypothesis is that pedSS has a different presentation and pathophysiology than adult SS, with more genetic involvement. To test this hypothesis, we define the following specific aims: define disease presentation of children with SS-like…
The aim of this study is to explore differences in expression of Rac1 and pSTAT3 in leucocytes of therapy-naïve IBD patients, IBD patients on immune suppressive therapy and healthy controls.
In the current *proof of principle* study, it is hypothesized that ex vivo expansion of Tregs originating from patients with the prototypic examples from the spectrum of autoimmune or inflammatory diseases (SLE, AAV, MS or CD) can be accomplished by…
To investigate the difference in number, phenotype and function of plasmacytoid dendritic cells and T cells in and between patients with SSc, LS and EF and between patients with these diseases and healthy controls / patients with psoriasis.
The primary (research) objective of this project is to determine the magnitude of the disease burden of neurocoeliac disease in the Netherlands by studying the prevalence of coeliac disease or gluten sensitivity in ataxia patients. The secondary…
The primary objective of this study is to assess the prevalence of Temporomandibular Joint Disorders in (1) rheumatoid arthritis (RA) patients, (2) individuals at increased risk of RA, and (3) a control group without autoimmune diseases and to…
Objective 1. To investigate whether LECs from the skin of PsA patients, in contrast to that of PsO, are capable of inducing a homing receptor profile that favors a T-cell migratory response towards the synovial joint on skin-derived, allogenic T-…
To investigate whether patients with autoimmune joint diseases have higher sodium concentrations in their inflamed joints and in tissues know to act as sodium storage locations: skin and muscle, as compared to healthy controls. Secondary Objective:1…
The purpose of this study is to investigate the effect of the study compound efgartigimod on the immune system's response to vaccination with Pneumovax 23. We also investigate how safe efgartigimod is and how well it is tolerated when it is…
The primary objective is to compare pancreatic macrophage infiltration between individuals with T1D and controls by imaging intracellular iron particle accumulation in macrophages by late-phase MR imaging. To achieve this we will first develop an…
We aim to perform an in-depth investigation into the role of the mucosal immune response in the pathogenesis of rheumatoid arthritis. Our objectives are to study the presence of RA-specific autoantibodies and several other biomarkers (cytokines,…
Primary objective: To evaluate, in a cohort of non-tested individuals who reported flu-like symptoms during the COVID19 epidemic in the Netherlands (March-November), the seroprevalence of COVID19 in patients with an IMID, with or without…
Part 1 - Single Ascending Dose (SAD) Capsule Formulation:Primary objective:To investigate the safety and tolerability of single oral doses of R289 capsules in healthy subjects.Secondary objective:To characterize the pharmacokinetic (PK) profiles of…
This study has been transitioned to CTIS with ID 2024-518965-85-00 check the CTIS register for the current data. The primary objective of this study is to investigate the potential differential effects of RTX and OBI on the composition of lymph…
Primary objective: To investigate whether AS patients have increased signs of microvascular abnormalities of the retina, compared with healthy controls.Secondary objectives: to investigate:1. the peripheral microvascular function in AS patients,…
Primary Objective:The primary objective of this study is to provide confirmatory data on the beneficial effect of 2.0 g/kg of Octagam 10% given every 4 weeks compared with placebo in subjects with active DM based on the percentage of responders at…