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A Phase 4 Cross-Sectional Study of Bone Mineral Density in HIV-1 Infected Subjects

To characterize the profile of low BMD in >= 50 years old male HIV-1 infected subjects andpost-menopausal female HIV-1 infected subjects taking TDF-based regimens relative tothose taking non-TDF-based regimens for HIV infection.

A prospective open-label study to investigate the effects of switching to a darunavir based regimen on low level viremia, immune activation and neurocognitive performance in patients on antiviral therapy.

To suppress low-level viremia to a level below 50cp/mL in patients using cART by switching their current non-nucleoside reverse transcriptase inhibitor (NNRTI) or PI to DRV boosted with ritonavir (RTV) (DRV/r). Secondary objectives are to reduce the…