23 results
Our hypothesis is that antibodies of COPD patients contribute to inflammatory processes leading to cell death, and that the level of cytotoxicity differs between COPD patients and healthy volunteers. The prime aim is to detect differences in…
To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.
1. To describe the development of the nature of the immune system in early life in a profile of cytokines, chemokines and adipokines. 2. To evaluate less invasive methods like the use of saliva or less demanding methods like the use of dried bloods…
Primary Objective: The main objective of this study is to analyse the effects of pregnancy on levels and percentages of CD8 cell subsets in peripheral blood both during and after pregnancy.
To investigate the relation between a known genetic variation in a set of selected genes involved in the recognition of microorganisms and inflammation and the frequency of respiratory tract infections in a group of children with DS.
The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.
Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.
This study will investigate fatigue after exercise in sarcoidosis patients. It will determine the severity of their fatigue, the recuperative capacity after maximal exertion (bicycle ergometer) and the levels of ACE and cytokines (before and after…
The general objective of this study is to elucidate the cellular components for HIV-1 infection in children.
The main objective is to identify a difference in mRNA expression level of IFN and IFN related genes between Down Syndrome children and a control group of healthy children (siblings). The secondary objective is to identify a relationship between…
Research questions:Is the chronic inflammatory response in COPD caused by a dysfunction of regulatory T cells?1. Is the number of Tregs decreased in COPD?2. Is the function of the Tregs impaired in COPD? And if so,a. Is this associated with a…
The objective of the study is the falsification of the following null hypotheses:1. The pro-inflammatory status of the innate immune system of normal fertile women and the of women with idiopatic subfertility are not different.2. The profile of the…
The main objective of this study is to analyse the effect of fetal sex on levels of T and macrophage cell subsets in decidual tissue. Secondary objectives will be to analyse differences in the effect of maternal blood stimulation by fetal leukocytes…
Aim of the study:To investigate the role of the CD200/CD200R axis on the responsiveness of whole blood, peripheral blood mononuclear cells (PBMCs) and neutrophils to a proinflammatory challenge in the immunoparalysed state in sepsis patients.…
Primary objective:Investigate if a trained immunity profile in innate immune cells might be a mechanism of HIV elite control.Secondary objectives:1. Determine the immune phenotypes that distinguishes family members of HIV elite controllers from…
The goal of this study is to obtain insight into possible differences in macrophage and monocyte populations in uncomplicated pregnancies and pregnancies complicated by FGR.
AimThe MAPS study aims to unravel the immune composition of the human peritoneal cavity and the tumor immune environment in peritoneal metastasized gastric and colorectal cancer. The overarching aim is to find new targets for immunotherapy for this…
The aims of this study are:1. To describe the neuropsychiatric profiles associated with DDX3X syndrome, SETD1A syndrome, Koolen-De Vries syndrome, KBG syndrome, DYRK1A syndrome, Jansen-De Vries syndrome, Gabriele-De Vries syndrome, and Smith-Magenis…
Research objective: Transcriptome data from main immune cell types (monocytes, CD4+ and CD8+ T cells, B-cells, NK cells) of post-COVID patients are analyzed using STP technology. STP-activity results are interpreted in combination with clinical…
This study aims to delineate the alterations in leukocyte function during ex-vivo host-pathogen interactions. These data will be correlated with several factors such as coexisting comorbidities (e.g. diabetes) and functional defects analyzed using…