51 results
Research questions:Is the chronic inflammatory response in COPD caused by a dysfunction of regulatory T cells?1. Is the number of Tregs decreased in COPD?2. Is the function of the Tregs impaired in COPD? And if so,a. Is this associated with a…
The objective of the study is the falsification of the following null hypotheses:1. The pro-inflammatory status of the innate immune system of normal fertile women and the of women with idiopatic subfertility are not different.2. The profile of the…
The main objective of this study is to analyse the effect of fetal sex on levels of T and macrophage cell subsets in decidual tissue. Secondary objectives will be to analyse differences in the effect of maternal blood stimulation by fetal leukocytes…
Aim of the study:To investigate the role of the CD200/CD200R axis on the responsiveness of whole blood, peripheral blood mononuclear cells (PBMCs) and neutrophils to a proinflammatory challenge in the immunoparalysed state in sepsis patients.…
Primary objective:Investigate if a trained immunity profile in innate immune cells might be a mechanism of HIV elite control.Secondary objectives:1. Determine the immune phenotypes that distinguishes family members of HIV elite controllers from…
The goal of this study is to obtain insight into possible differences in macrophage and monocyte populations in uncomplicated pregnancies and pregnancies complicated by FGR.
Primary Objective: analyse the effect of maternal BMI on levels of macrophage cell and monocyte subsets in decidual tissue and maternal blood. Secondary Objective: analyse differences in the effect of maternal blood stimulation with conditioned…
The objectives of this study are to:• Assess safety and tolerability of imlifidase in combination with standard IVIg treatment in GBS subjects• Evaluate pharmacokinetics of imlifidase• Evaluate pharmacodynamics profile of imlifidase• Evaluate…
AimThe MAPS study aims to unravel the immune composition of the human peritoneal cavity and the tumor immune environment in peritoneal metastasized gastric and colorectal cancer. The overarching aim is to find new targets for immunotherapy for this…
This study has been transitioned to CTIS with ID 2024-512579-11-00 check the CTIS register for the current data. Primary:- To evaluate the short-term safety and tolerability of TX200-TR101 from the day of TX200 TR101 infusion within 28 days post…
The aims of this study are:1. To describe the neuropsychiatric profiles associated with DDX3X syndrome, SETD1A syndrome, Koolen-De Vries syndrome, KBG syndrome, DYRK1A syndrome, Jansen-De Vries syndrome, Gabriele-De Vries syndrome, and Smith-Magenis…
To test the hypotheses that patients who show severe fatigue after COVID-19 infection exhibit an exaggerated abnormal expression of inflammatory monocyte genes (particularly of the genes involved in pyroptosis, such as IL-1 and IL-6) as compared to…
This study has been transitioned to CTIS with ID 2024-512580-31-00 check the CTIS register for the current data. PrimaryTo evaluate the long-term safety and tolerability of TX200-TR101 up to 15 years post-TX200-TR101 infusion/baseline.SecondaryTo…
To assess whether premature aging of both the innate and adaptive arms of theimmune system are associated with COVID-19 morbidity and mortality. Identify immune (andendocrine) parameters that might be of use in predicting disease progression and…
Research objective: Transcriptome data from main immune cell types (monocytes, CD4+ and CD8+ T cells, B-cells, NK cells) of post-COVID patients are analyzed using STP technology. STP-activity results are interpreted in combination with clinical…
PRIMARY OBJECTIVE: -To assess the antibody response after mRNA (Pfizer, Moderna) SARS-CoV-2 vaccination in children with cancerSECONDARY OBJECTIVES:To assess in children with cancer after SARS-CoV 2 vaccination:- durability of the antibody response…
To investigate the therapeutic efficacy and feasibility of hyperbaric oxygen (HBO) in addition to standard wound care in patients with pyoderma gangrenosum wounds.
Primary ObjectiveIn order to assess the effects of anti TNFα on the development of adaptive and innate immunity, children exposed to anti TNFα (with or without other immunosuppressive drugs) will be compared to children exposed to immunosuppressive…
To assess the antibody response after SARS-CoV-2 vaccination in people >=16 years and children with Down Syndrome. Part 2To assess the antibody response after a third SARS-CoV-2 vaccination in adults and children with Down Syndrome and to…
This study aims to delineate the alterations in leukocyte function during ex-vivo host-pathogen interactions. These data will be correlated with several factors such as coexisting comorbidities (e.g. diabetes) and functional defects analyzed using…