Search for a trial

A double-blind, randomized-withdrawal, placebo-controlled study to evaluate the efficacy and safety of human plasma-derived C1-esterase inhibitor as add-on to standard of care for the treatment of refractory antibody mediated rejection in adult renal transplant recipients

The primary objective of the study is to evaluate the efficacy of C1-INH in the treatment of refractory AMR in renal allograft recipients.The secondary objectives of the study are:1. To further evaluate the efficacy of C1-INH in the treatment of…

Explorative study to the effect of BCG booster methods on the induction of trained innate immunity

The objective of the study is to determine the effect of BCG revaccination and high dose BCG vaccination on the induction and course of innate immune memory.

PILOT STUDY: WEB-BASED TREATMENT OF SEVERE FATIGUE AMONG ADOLESCENT PATIENTS WITH AN IMMUNE DYSREGULATION DISORDER: A SINGLE-CASE EXPERIMENTAL DESIGN WITH MULTIPLE MEASUREMENTS.

1. To investigate the feasibility of web-based cognitive CBT among severely fatigued adolescent patients with an immune dysregulation disorder, and 2. To estimate intervention effects on reducing fatigue, associated chronic pain and fatigue related…

Understanding colchicine resistance in Familial Mediterranean Fever; exploring pathophysiological mechanisms and therapeutic options

The primary objective is to identify what causes colchicine resistance in FMF. Additionally, we will try to identify potential interventions to overcome resistance

COBRA re-KAI study: COVID-19 vaccination in patients with reduced B-cell and T-cell immunity: response after re-vaccination of a kaleidoscopic group of hematological patients: what*s the impact?

To answer the following questions: 1. Who are the patients that need to be revaccinated?2. How many vaccinations are needed to restore SARS-CoV-2 immunity?3. Can the number of vaccinations needed to restore SARS-CoV-2 immunity be predicted?To answer…

Vaccinations in the Immunocompromised population: paramount and paradox.

The objective of this study is to determine the immune response after hepatitis A and pneumococcal vaccination in different groups of ICPs. The overarching aim of the study is to improve vaccine regimens and to optimize guideline recommendations…

Immunity to varicella-zoster virus in immunocompromised renal disease patients

More knowledge on immunity to VZV in these patient groups is necessary to be able to design preventive strategies to VZV infections in the future. To reach these goals, the proposed study is divided into two parts. The first part aims to determine…

Does a deregulated PI3K/Akt-pathway affect the immune system in children with Down syndrome?

1. To examine whether the PI3K-AKT pathway is overly activated in children with Down syndrome compared to healthy age-matched controls. 2. To determine the rate of exhaustion and the apoptosis of lymphocytes in children with DS. 3. To determine the…

The antibody response to pneumococcal vaccination in patients
with inflammatory bowel disease patients treated with immunosuppressive agents

Primary objective: to determine the vaccine efficacy of PCV13 plus PPV23 (2-month series) in cases, i.e. IBD patients treated with immunosuppressive agents, vs controls. Secondary objectives: - To assess if the use of a TNF-alpha inhibitor affects…

Cell subsets in blood as a biomarker for Bronchiolitis Obliterans Syndrome (BOS)

The objective of this study is to determine the composition and functional capacity of leukocyte fractions in the blood of lung transplantation patients. As a possible biomarker for BOS. It is expected that in patients with BOS the frequency and…

Long-term follow-up of the offspring born to mothers with a solid organ transplant.

The primary aim of the study is to assess the overall health of offspring born to a mother with solid organ transplantation, and to identify possible pre- and perinatal risks for diseases later in life. In addition, we would like to collect and…