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Observational multi-center, prospective study to develop a novel multi-parametric diagnostic model for hospitalized patients and patients on the Emergency Department presenting with lower respiratory tract infections and/ or sepsis.

To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.

Community Acquired Pneumonia: Outcome, Quality of Life and Immune Status

The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.

A multi-center, prospective, blinded validation study to assess the accuracy of a host-response based diagnostics for distinguishing between bacterIal and viral etiology in pediatric patients with lower respiratory tract infections and fever without source

To externally validate the accuracy of a host-response based diagnostics for differentiating between bacterial and viral etiology in pediatric patients aged 2 to 60 months with LRTI or FWS.

The role of innate lymphoid cells in asthma and rhinovirus-induced asthma exacerbations

This study aims to determine whether the ILC populations differ in the lungs of different phenotypes of asthmatic patients and healthy subjects and how these cells are regulated by bronchial epithelial cells. Furthermore we want to study how this is…

Understanding Q-detect: Coxiella burnetii exposure and the humoral and cellular immune response

(i) to determine specificity of Q-detect* for registration purposes. (ii) to design a decision tree for follow-up of patients with a positive Q-detect* and

Activation and apoptosis of peripheral T cells in relation to liver fibrosis

The primary objective is to explore the association between peripheral T-cell activation and apoptosis and hepatic fibrosis in various underlying liver diseases. Secondary objectives are 1) to investigate whether level of T cell activation and…

Validation of Interferon Gamma Release Assays (IGRA) using frozen Peripheral Blood Mononuclear Cells (PBMC)

Determining the impact of freezing PBMC on the test result of the IGRA.

Molecular detection of the bacterial load as a diagnostic and monitoring tool for optimal antibiotic treatment in endocarditis

Primary objectives:- Evaluation of the value of mBL as a diagnostic tool for bacterial endocarditis.- Evaluation of the value of mBL as a monitoring tool during treatment for bacterial endocarditis.- To obtain data on the kinetics of mBL related to…

The ART-NECO study;Long term effective combination antiretroviral therapy (cART) and its effect on neurocognition. A prospective cohort study to assess the feasibility of two short cognitive screen tests in patients infected with HIV1 and the development of neurocognitive impairment over time

To examine neurocognition in 100 HIV1 seropositive patients on chronic effective cART using three different tests: the Montreal cognitive assessment (MoCA) , the International Aids Dementia scale (ADS) and extensive neuropsychological testing of…

T cell Response in Q fever (TRIQ-study)

Primary Objective: To determine T cell response to Coxiella burnetii antigens using an ELISPOT interferon gamma release assay in patients with different clinical outcomes after acute Q fever

Comparison of assays for Borrelia detection

To investigate the diagnostic properties of Borrelia immunoblots from various manufacturers and compare the diagnostic properties of different bands, and to validate the diagnostic value of B. burgdorferi PCR on blood and urine.

the Application of an Electronic Nose in the Early detection of Aspergillosis II

1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…

Feasibility of Diffusion Tensor Imaging MRI in post-polio syndrome

The main objective of this study is to compare DTI findings of PPS patients with those of healthy controls. Secondary objective of this study is to correlate DTI findings with clinical data such as isometric muscle strength. Third objective is to…

Q Herpen II, Post outbreak screening in a Q fever high incidence area for late consequences of Q fever including chronic Q Fever.

This study will provide a robust estimate of the prevalence of C. Burnetii exposure and possible chronic Q fever among asymptomatic participants. This is important in order to assess whether population screening in a high incidence area is useful…

Enhancement of the sensitivity of a whole-blood interferon gamma assay (Quantiferon TB Gold) for diagnosis of latent tuberculosis infection

Enhancement of the sensitivity of the Quantiferon test for patients with an inflammatory disease who are screened for presence of latent tuberculosis infection.

MOODINFLAME - Early diagnosis, treatment and prevention of mood disorders targeting the activated inflammatory response system - Bipolar patients cohort

To evaluate two biomarker tests (characterized by an activated inflammatory response system (IRS) as reflected by an aberrant monocyte gene expression signature and/or a disturbed metabolism of tryptophan) by comparing patients with BD with healthy…

Enterovirus- and parechovirus infection in Dutch children: epidemiology, diagnosis and prognosis

Primary objectives:(1) To describe the incidence of EV and HPeV infections in Dutch children(2) To determine the major symptoms of EV/HPeV infections in children(3) To evaluate the epidemiology and symptoms of the different subtypes of EV and HPeV(4…

Prestudy Optimizing Diagnosis of Community-Acquired Pneumonia

The objective of the standardized protocol is optimalizing the accuracy of the diagnosis (all-cause pneumonia, or serotype-specific pneumonia) during the 13-valent pneumococcal vaccin (13vPnC) study which will be performed in 2008. Additionaly, the…

Influence of haemodialysis on the in vitro mitogenic function and interferon-gamma production of the CD4- and CD8-positive T-lymphocytes in patients undergoing chronic heamodialysis

To determine the general usefulness of and a proper moment when blood should be taken for the in vitro IFN-γ assays in patients undergoing chronic haemodialysis.

the Application of an Electronic Nose in the Early detection of ASpergillosis

to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls