Search for a trial

Steatosis of the liver in adolescents born small for gestational age (SGA) after prolonged growth hormone treatment for small stature.

Goal of this study is to investigate whether hepatic steatosis can be found in adolescents born SGA who have had prolonged GH treatment because of short stature. A possible relationship between hepatic steatosis and insulin sensitivity, adipose…

The role of paroxetine in patients taking telaprevir-based HCV therapy: lack of a drug-drug interaction? (ROLEX)

Primary objective:To show that concomitant use of telaprevir (1125 mg BID) does not lead to a relevant decrease (> 20%) in the paroxetine parameter AUC0-24h compared to paroxetine alone.Secondary objectives:To determine the ratio of the…

A Randomized Study of Stopping Treatment at 24 Weeks or Continuing Treatment to 48 Weeks in Treatment-Naïve Subjects with Genotype 1 Chronic Hepatitis C who Achieve an Extended Rapid Viral Response (eRVR) While Receiving Telaprevir, Peginterferon Alfa2a (Pegasys®) and Ribavirin (Copegus®)

Primary:To estimate the difference in SVR rates between T12/PR24 and T12/PR48 treatment regimens in subjects who achieve eRVR.Secondary:To evaluate the safety of telaprevir in combination with Peg-IFN-alfa-2a and RBV in treatment-naïve subjects with…

Long-term neurodevelopment in patients treated for biliary atresia

This study aims to investigate neurodevelopment in primary school children surviving biliary atresia when compared to a healthy reference group. Second aim is to identify prognostic factors associated with a worse outcome in these children.

Rehabilitation after liver transplantation? A study into the applicability and feasibility of rehabilitation in liver transplant recipients.

Aim of the preceding study is to explore the applicability and feasibility of a rehabilitation program for improvement of complaints of fatigue in liver transplant recipients.

Long term effect of bile duct injury in gallbladder surgery.

Evaluation of quality of life and resoration of function after bile duct injury.

Pharmacokinetics of UDCA in serum and bile in patients with early stage PBC (stage I-III) and in healthy volunteers

To assess the bile acid composition of cystic bile and serum pharmacokinetics after a 3-week treatment with UDCA and to correlate pharmacokinetic parameter sof UDCA in bile and serum during steady state.To compare the composition of bile acids and…

Current use of anticoagulants in cirrhosis: a prospective study.

Primary Objective: To assess whether the current use and dosing in cirrhosis of anticoagulation is as effective in inhibiting ex vivo thrombin generation compared to the treatment of patients with competent liver function

The Efficacy of Pro- and Anticoagulant Therapy in Plasma of Patients with Cirrhosis undergoing Orthotopic Liver Transplantation

To investigate the in vitro effect of both pro- and anticoagulation therapy on thrombin generation by Calibrated Automated Thrombography in plasma from patients with cirrhosis undergoing liver transplantation.

The treatment of venous thromboembolism with edoxaban in patients with cirrhosis, a pharmacokinetic study.

To assess the safety and effect of edoxaban in Chil-Pugh B cirrhosis.

Prolonged Dual Hypothermic Oxygenated Machine Preservation of Human Liver Grafts: A Feasibility Trial

To study the safety and efficacy of prolonged (>2 hours) end-ischemic DHOPE, by assessing the occurrence of (serious) adverse events during machine perfusion and within 30 days after liver transplantation.

Long-term hepatotoxicity of azathioprine, 6-mercaptopurine and 6-thioguanine in IBD patients

Assess hepatotoxicity of long-term azathioprine and 6-mercaptopurine use in IBD-patients as compared with a cohort of long-term 6TG users

A PHASE I, SPONSOR-OPEN, INVESTIGATORBLINDED,SUBJECT-BLINDED, MULTI-CENTER,
PLACEBO-CONTROLLED STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS
AND PHARMACODYNAMICS OF ORAL ADMINISTRATION OF RO7020531: (1). SINGLE
AND MULTIPLE ASCENDING DOSES IN HEALTHY MALE AND FEMALE SUBJECTS; (2). 6-WEEK
TREATMENT OF VIROLOGICALLY SUPPRESSED PATIENTS WITH CHRONIC HEPATITIS B VIRUS
INFECTION

OBJECTIVESPrimary ObjectivesThe primary objective is:* To assess the safety and tolerability of 6 weeks of treatment with RO7020531 administered orally to virologically suppressed chronic hepatitis B (CHB) patients.Secondary ObjectivesThe secondary…

Pharmacokinetics of tacrolimus during pregnancy in kidney and liver transplant recipients.

The overall aim of the study is to gain more insight in as well as understand and map the pharmacokinetics of tacrolimus during pregnancy. Therefore, we will study tacrolimus concentrations in maternal whole blood (routine care) and via area under…

A randomized, double-blind, dose-ranging, placebo-controlled, Phase 2a evaluation of the safety, tolerability, and pharmacokinetics of PLN-74809 in participants with primary sclerosing cholangitis (PSC) and suspected liver fibrosis (INTEGRIS-PSC)

To assess the safety and tolerability of PLN 74809 in participants with PSC and suspected liver fibrosis

The ex-vivo potency of Edoxaban in patients with cirrhosis

Primary Objective: To assess the ex-vivo anticoagulant potency of Edoxaban in patients with Child Pugh A/B cirrhosis, by means of percentual changes in ex-vivo thrombin generation from baseline compared to steady state. These results will be…