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Enzyme substitution in exocrine pancreatic insufficiency; Self administration against a fixed dose regimen.

To assess the difference in efficacy of pancreatic enzymes in a self-dosage regimen after extensive patient-education in comparison to the standard treatment for patients with EPI.

Acute biliary Pancreatits: early ERC plus sphincterotomy versus Conservative treatment: the APEC trial, a randomized, superiority, assessor-blinded multicenter trial.

The objective of the study is to investigate whether early ERC plus ES in patients with suspected APB and a predicted severe disease course without cholangitis, lowers the incidence of a composite endpoint of mortality and severe morbidity. Major…

AXIOMA: Hot AXIOS metal stent for infected walled-off pancreatic necrosis management.

Investigate whether the use of the Hot AXIOS lumen apposing metal stent is superior to standard plastic pigtails stents for drainage of infected pancreatic necrosis.

Pancreatic cancer: validation of circulating predictive biomarkers

To validate promising circulating predictive biomarkers for FOLFIRINOX response in patients with PDAC, found in our previous pilot cohort (iKnowIT study, NL65025.078.18, MEC-2018-087) and to generate a biobank of blood samples to investigate future…

APpendix derived PAncreatic cancer Reactive T-lymphocytes

To evaluate anti-tumor activity of T-cells in the GALT of patients with PDAC.