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An open-label, phase II, single-arm study of everolimus in combination with letrozole in the treatment of postmenopausal women with estrogen receptor positive metastatic breast cancer (CRAD001Y24135)

Primary: to estimate progression-free survival in patients treated with everolimus + letrozole in the first line setting.Secondary: overall response rate, clinical benefit rate, overall survival in the first line setting, progression free survival…

Pilot study on the use of a radiopaque hydrogel during breast conserving surgery with full-thickness closure for target definition and positioning of boost or partial breast irradiation.

Primary objective: Estimate the Conformity Index (Cx) of target definition. Secondary objectives: Estimate the distance between the center of mass (dCOM) of the observers* target volumes, Cavity Visualisation Score (CVS), feasibility of the hydrogel…