14 results
The main purpose of this study is to determine the side effects of trastuzumab when it is given by each of these subcutaneous injection methods. The study will also gather information about whether and when the cancer comes back after taking…
A phase Ib / II randomized study of BI 836845 in combination with exemestane and everolimus versus exemestane and everolimus alone in women with locally advanced or metastatic breast cancer.With following objectives:Phase Ib part: To determine the…
The objective of this study is to investigate the relation between tamoxifen use during COS, endoxifen levels reached during COS, and recurrence-free survival (locoregional recurrence, distant recurrence or death from any cause) when compared with…
Primary: to estimate progression-free survival in patients treated with everolimus + letrozole in the first line setting.Secondary: overall response rate, clinical benefit rate, overall survival in the first line setting, progression free survival…
The primary objective is to evaluate whether SLNB can safely be omitted in breast cancer patients with HER2+ or TN tumors who achieve rCR on MRI after NST. Secondary, quality of life will be assessed in patients with and without SLNB.
To determine the potential pharmacokinetic interaction between CBD and endoxifen.Secondary objective: To investigate side effects of CBD and to determine the pharmacokinetic profile of CBD
To assess whether HBOT reduces pain, and improves physical functioning and QoL in breast cancer patients with late radiation toxicity.
The primary objective of this study is to determine the proportion of patients that reach an endoxifen level of 16 nmol/L or higher using MIPD. Secondary objectives: 1. To determine the total success rate of the POP-PK model as well as in different…
The primary objective of this trial is to compare the number of postoperative wound complications in patients with and without negative pressure therapy after breast conserving surgery in the first three months after surgery. Wound complications…
Primary objective: Estimate the Conformity Index (Cx) of target definition. Secondary objectives: Estimate the distance between the center of mass (dCOM) of the observers* target volumes, Cavity Visualisation Score (CVS), feasibility of the hydrogel…
To determine the influence of concomitant administration of tamoxifen and probenecid on tamoxifen and endoxifen(-glucuronide) plasma concentrations
To evaluate if the use of Hemopatch in axillary lymph node dissection shows potential in reducing clinically significant seroma and seroma related complications, which might serve as a basis for a randomized controlled trial.
Aim of this study is to assess the effects of exercise intervention on breast cancer patients* quality of life on the short (6 months) and long-term (24 months) according to the cmRCT design and to test the utility of the cmRCT design in the field…
Confirm favorable treatment results of international studies.Relate (loco regional) tumor control, side effects and (inter current) death to geriatric questionnaires/condition, co-morbidity and usage of medication.