45 results
The main purpose of this study is to determine the side effects of trastuzumab when it is given by each of these subcutaneous injection methods. The study will also gather information about whether and when the cancer comes back after taking…
The aims of this project are to:1. Assess what percentage of breast cancer patients experience accelerated gain in fat mass, loss of muscle mass and muscle strength as induced during chemotherapy2. Assess whether changes in energy intake, protein…
Investigate the association between BRCA1/2-mutations, DNA damage, apoptosis and oocyte/embryo quality in immature germinal vesicle (GV) bearing oocytes, immature metaphase 1 (MI) and unfertilized mature metaphase 2 (MII) oocytes and affected early-…
To assess whether the use of RFIB instead of LCNB increases the probability of a definitive preoperative histological diagnosis in women with suspicious mammographic breast lesions. assess the *RFIB success rate*, defined as the proportion of…
A phase Ib / II randomized study of BI 836845 in combination with exemestane and everolimus versus exemestane and everolimus alone in women with locally advanced or metastatic breast cancer.With following objectives:Phase Ib part: To determine the…
To study prevalence and consequences of cognitive, psychological, social and functional decline in elderly breast cancer patients, in comparison to a population elderly without breast cancer.
The purpose of this study is to investigate whether the pre-operative contrast enhanced CT scan can be used for determination of the pre-operative tumour localisation, with the aim of increasing the accuracy of the boost area. If so, the boost…
Primairy objective: we will examine the difference in VOC pattern of exhaled air between patients with histology-confirmed diagnoses of non small cell lung cancer vs breast cancer. Secundairy objective: a. to confirm the potential of the electronic…
The objective of this study is to determine the accuracy of the sentinel lymph node biopsy in multicentric breast cancer prospectively and multi-institutional.
Optimalisation of genetic counseling for patients with breast cancer, by also making use of other ways to provide information than the personal consultation.
We intend to study the effect of trastuzumab on the cardiac neuronal activity in patients with HER-2 positive breast cancer by using iodine-123 meta-iodobenzylguanidine (123I-MIBG) and cardiac imaging. 123I-MIBG, an analogue of the false…
Primary Objective: Does long-term endocrine adjuvant treatment for breast cancer lead to structural changes in the brain and to functional changes in brain-wide networks, and do these changes correlate with cognitive impairment induced by the…
1. Developing novel approaches to determine the clinical significance of UVs. 2. Developing new clinical guidelines and implement them into clinical practice.
We will investigate if irradiation of part of the heart leads to cardiac sympathetic innervation injury and subsequently to radiation induced cardiovascular disease.
The objective of this study is to investigate the relation between tamoxifen use during COS, endoxifen levels reached during COS, and recurrence-free survival (locoregional recurrence, distant recurrence or death from any cause) when compared with…
Our objective is to test the feasibility and preliminary effects of a web-based patient portal containing a survivorship care plan, online questionnaires for symptoms and HRQL with personalized feedback and a physical activity support programme that…
·To compare the serological response to influenza vaccination in mamma carcinoma patients treated with FEC-containing, triweekly regimens at day 4 ( +/- 1 day) of the chemotherapy cyclus with the response to vaccination in otherwise healthy patients…
The primary aim of the study is to identify breast cancer patients who experience objective and/ or subjective cognitive dysfunction one year after chemotherapy and find determinants of this cognitive dysfunction on patients' quality of life…
The aim of the study will be to examine the relationship between personality, QoL and diurnal cortisol rhythm in women with a suspicion of breast cancer with regard to morbidity, prognosis and mortality.
Riskreduction of developing breast carcinoma by means of better surgical techniques (removing all normal breast tissue).