45 results
Main and long-term goal of this project is to gain more knowledge of the relationship between genome-wide genetic variation and the risk of breast cancer, in the context of a positive family history. This knowledge will improve individual risk…
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The aim of this study is to investigate whether single nucleotide polymorphisms can increase the sensitivity and specificity of serum markers in breast cancer diagnostics.
Primary: to estimate progression-free survival in patients treated with everolimus + letrozole in the first line setting.Secondary: overall response rate, clinical benefit rate, overall survival in the first line setting, progression free survival…
The primary objective is to evaluate whether SLNB can safely be omitted in breast cancer patients with HER2+ or TN tumors who achieve rCR on MRI after NST. Secondary, quality of life will be assessed in patients with and without SLNB.
To determine the potential pharmacokinetic interaction between CBD and endoxifen.Secondary objective: To investigate side effects of CBD and to determine the pharmacokinetic profile of CBD
The aim of the here proposed study (BLOC-II) is to clarify whether cardiac function in survivors of BC should be monitored by GPs. We expect to clarify whether an unselected population of long-term BC survivors is at increased risk of developing…
The objective of this study is to evaluate the (nationwide and international) implementation of ICG-fluorescence for SN-procedures for patients with breast cancer.
To assess whether adjuvant chemotherapy can be safely omitted in patients with pathological stage I (pT1a/b/cN0) TNBC and a high sTIL score (defined as >=50% for patients <40 years at the time of TNBC diagnosis; >=75% for…
The primary end-point is ipsilateral invasive breast tumor-free rate at 10 years. Secondary end-points are among others: overall survival, breast cancer-specific survival, mastectomy rate and patient reported outcomes.To determine whether low- risk…
- To study sensitivity and specificity of the MeD-seq test for detection of BrCa in female BRCA1/2 mutation carriers in an early stage.- To determine if the MeD-seq test can detect BrCa earlier in time than current surveillance tools (MRI/…
To assess whether HBOT reduces pain, and improves physical functioning and QoL in breast cancer patients with late radiation toxicity.
The INFINITE trail aims to successfully implement ICG-fluorescence for identifying the SLN by: 1) guiding the implementation process using the Effective Implementation of Change model developed by Grol and Wensing; 2) identifying and understanding…
The primary objective of this study is to determine the proportion of patients that reach an endoxifen level of 16 nmol/L or higher using MIPD. Secondary objectives: 1. To determine the total success rate of the POP-PK model as well as in different…
Early detecction of breast cancer in women with high risk of developing breast cancer with protein and glycan biomarkers.
The primary objective of this trial is to compare the number of postoperative wound complications in patients with and without negative pressure therapy after breast conserving surgery in the first three months after surgery. Wound complications…
To set up a cohort of breast cancer patients, collecting information on patient characteristics, short and long-term clinical and patient reported data, and to compare outcomes with a healthy refrence population. whichThe cohort will also serve as…
In this pilot, we aim to improve the detection rate of LM by using the CellSearch technique quantifying circulating tumor cells (CTCs) in cerebrospinal fluid (CSF, i.e. CSFCTs) and compare this with the current standard of care; namely cytological…
Primary objective: Estimate the Conformity Index (Cx) of target definition. Secondary objectives: Estimate the distance between the center of mass (dCOM) of the observers* target volumes, Cavity Visualisation Score (CVS), feasibility of the hydrogel…
To determine the difference in change over time of cognitive function and brain magnetic resonance imaging (MRI) measurements between breast cancer survivors and cancer-free individuals.