14 results
Primary objective: To study the influence of repeated oral administration of ketoconazole, a potent CYP3A4 inhibitor, in a therapeutic dose on the plasma pharmacokinetics (PK) of eribulin administered via intravenous (IV) infusion.Secondary…
The objective of this study is to determine the prevalence of xerostomia after radiotherapy of oropharyngeal tumors when sparing the parotid glands and one submandibular gland.
Primary• To determine the safety profile of oral topotecan in subjects with cancer andmildly moderately or severely impaired renal function (Groups C, D and E) compared to subjects with cancerwhose renal function is normal and who have received…
To investigate the effect of enzalutamide on the pharmacokinetics (PK) of oxycodone following a single 15 mg oral dose of normal-release oxycodone in men with prostate cancer.
In the coming months, immunocompromised patients treated in our hospital will be requested to undergo vaccination if they comply with the National Institute for Public Health guidelines. For all subgroups, it is of utmost importance to assess the…
To assess immune response and adverse events after administration of one approved vaccine against COVID-19 in patients with cancer treated with immunotherapy and/or chemotherapy
This study has been transitioned to CTIS with ID 2023-508530-34-00 check the CTIS register for the current data. Primary objective:* To demonstrate the efficacy of alpelisib as measured by the proportion of participants randomized to alpelisib with…
To evaluate whether a family involvement program comprising a set of evidence-based basic care activities reduces the number of unplanned readmissions and postoperative complications after major abdominal surgery.
The aims of this project are to 1) to determine the non-inferiority of inter-CBT, compared to a benchmark study where CBT was provided by psychologists (TIRED study), in its effect on reduction in cancer-related fatigue, 2) to adapt CBT delivery to…
The primary objective of this study is to obtain clinically characterized, whole blood specimens from subjects with a new or suspected diagnosis of cancer (cancer subjects) and from subjects who do not have a diagnosis of cancer (healthy) to develop…
The aim of this study is both a feasibility study to gain a comprehensive understanding of the feasibility, satisfaction and impact, and trends of the effects of a physical exercise and nutritional intervention in patients who will be treated by a…
The objective of this study is to identify genetic variations associated with clinical response and toxicity in non-small cell lung cancer patients (NSCLC) undergoing chemoradiation or chemotherapy with platinum agents (carboplatin, cisplatin). The…
The aim of this study is to evaluate the changing over time of AA levels in plasma and in leukocytes before and during chemotherapy treatment for several different groups of patients and compare that to healthy controls.
To demonstrate that a dose reduction of 20-33% of CYP3A4 metabolized tyrosine kinase inhibitors in patients expressing the CYP3A4*22 gene (rs35599367 C>T in intron 6) does not result in a lower exposure (Ctrough) than the wildtype group with…