23 results
To provide clinical management and, if required, treatment to subjects who at their concluding HPV-015 study visit displayed normal cervical cytology but tested positive for oncogenic HPV infection or who were pregnant at their concluding visit of…
Objective: The primary goal of the current study is to study the immunogenicity and safety of HPV vaccination in patients with an autoimmune disease. Based on retrospective analysis with other vaccines we hypothesize that patients with autoimmune…
To determine the clinical effectiveness of adjuvant therapy given to all unstaged (no lymph node dissection) high risk stage 1 endometrial cancer, compared with only node positive (staged) cases as judged by full lymph node dissection.
The final aim of the research project is to investigate the optimal time (*window*) for vaccination after chemotherapy.• To explore the optimal time-window to start immunotherapy after chemotherapy;• To study the time-related immune response to…
Objective: The aim of this study is to investigate the potential role of microvesicles as novel biomarkers for ovarian cancer and to asses if their presence and characteristics are related to stage and prognosis.
To verify the feasibility of using the Pap-smear in diagnosing endometrial and ovarian cancer.
The aim of the study is to investigate the local levels of steroid-hormones compared to the peripheral levels in postmenopausal patients with endometrial hyperplasia, endometrial carcinoma and postmenopausal women without these diseases. This will…
Primary:To validate the latest version of DySIS in discriminating high grade (HG) from low grade (LG) lesions and non neoplastic tissue as well as in selecting the most atypical site for biopsy sampling, through digital documentation and…
Primary Objective:To identify suitable markers and their time course in order to better understand BEP chemotherapy induced oxidative stress in a minimally invasive manner.Secondary Objective:To measure the effect of chemotherapy on the elasticity…
The aim of this study is to investigate the structure and the biological behaviour of the peritoneum, in relation to the specific growth of EOC on the peritoneum, in order to identify the component of the peritoneum that maintains the blood-belly-…
The primary objective is to increase the percentage of elderly patients with ovarian cancer who complete standard or adapted therapy by using geriatric screening prior to start of therapy and to assess whether geriatric screening tests provide a…
We aim to identify diagnostic serum metabolite and protein biomarker signatures for early detection of cancer in asymptomatic high-risk population and prognostic biomarkers for selection of patients with poor prognosis.
To evaluate whether a less radical surgical approach with sentinel lymph node biopsy is non-inferior to treatment with systematic pelvic lymphadenectomy.The null hypothesis is that the recurrence rate after SLN biopsy is non-inferior to the…
This study aims to investigate the progression-free survival (PFS) according to RECIST 1.1 criteria on matched targeted therapy by STA-analysis (PFS2) in comparison to the PFS recorded on the therapy administered immediately prior to enrolment (PFS1…
Primary Objectives- To evaluate disease related characteristics in patients with different vulvar conditions compared to healthy volunteers - To evaluate the variability of the selected biomarkers between subjects, and within subjects over time.…
To study the value of molecular biomarkers in cytology samples (cervical scrape, vaginal sample and urine) for cancer detection in patients with gynaecologic cancer.
We expect the BMI and the type of fat distribution to have a significant influence on the change in hormone levels, fat metabolism and systemic inflammation levels after bilateral salpingo-oophorectomy (BSO). In patients with endometrial cancer,…
Primary objective:- To determine the difference in mean dose (Gy) to pelvic bones (whole pelvic contour), and the difference in the mean V15Gy-bowelbag volume in cc (according to EMBRACE bowel bag definition) between photon and proton therapy in…
To evaluate RRS after childbearing with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that delay of menopause leads to an improvement of quality of life and sexual functioning, and a decrease in…
The primary aim of this study is to investigate the effect of honey on the clearance of the hr-HPV virus in patients with CIN II.Secondary, the effect of honey on the normalization of CIN lesions, the role of the vaginal microbiome, the local immune…