21 results
1) Evaluating the effect and recovery of glioma surgery in eloquent areas on cognitive functioning.2) Examining the effec tof glioma surgery in eloquent areas on quality of life.3) Examining the effect of gliomas in eloquent areas on the…
Primary Objectives The main objective of this project is to evaluate the long-term disease burden in meningioma patients. More specifically, we will evaluate: 1) the level of cognitive functioning and HRQoL in meningioma patients at least 5 years…
Primary Objective: To assess whether both OCT (optical coherence tomography) and/or HSI (hyperspectral imaging) detect differences in glioma tissue as compared to healthy tissue as examined during brain-surgery.Secondary Objective(s): To assess if…
Primary Objective Our primary aim is to evaluate the course of cognitive functioning (stability, impairment or decline, or improvement as compared to Dutch controls) after usual care SRS in patients with 1-10 BM at time of treatment initiation.…
Primary Objective: 1) To study impairment and developmental delay in social cognition (and related cognitive functions) caused by brain damage in patients treated for a brain tumour in childhood as compared to a reference group of chronically ill…
The overall objective of the MOBI-KIDS study is to assess the potential carcinogenic effects of childhood and adolescent exposure to RF and ELF from mobile telephones on the central nervous system (CNS). In order to achieve the overall objective,…
The current study aims to investigate whether neural network characteristics of the brain can predict the frequency and severity of epileptic seizures in brain tumor patients. Our secondary objective is to determine the correlation between seizures…
This study is designed (1) to validate white matter tracts derived from DTI-FT with the results of ioESM, and (2) to develop RSFC analysis in order to quantify changes in functional connectivity patterns in patients that recover from neurosurgery-…
Primary Objectives: To identify the rate of successful AED withdrawal in LGG and anaplastic glioma patients with epilepsy and long-term seizure freedom after anti-tumour therapy. Secondary Objectives: - Exploring the physician*s and patient*s…
This study aims at determining to what extent brain tumor patients have limitations in social cognition, if these limitations are dependent on patient, tumor, or treatment characteristics, and how these limitations affect functioning of informal…
To determine if re-irradiation in 4 fractions is non-inferior to 10 fractions in the primary endpoint of survival after re-irradiation. Secondary objectives are to establish and compare health related quality of life (HRQoL), recurrence patterns,…
To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect changes in phospholipids and APT levels in paediatric brain tumours.
The main goal is to identify risk factors for radiation induced cognitive changes. Therefore, cerebral hemodynamic status of the patient, measured as cerebrovascular reactivity (CVR) with magnetic resonance imaging (MRI), at the start of radiation…
[Retrospective clinical path:1) main objective: to identify predictors (sociodemographic, clinical, imaging, and (neuro)psychological variables) of objective cognitive functioning of all patients who undergo neurosurgyer, at 3 months after surgery2…
Identifying the (immune) cell composition, co-localization, functions, and alterations as well as blood and lymph vessels reorganisation in the human*s dura, arachnoid and pia mater, and skull bone marrow in high-grade glioma patients as compared to…
To determine the value of and generate the clinical evidence for routine application of Whole Genome Sequencing (WGS)-based diagnostics and targeted therapy guidance for glioblastoma patients at time of first recurrence.
Primary objective:-To confirm that the Event-Free Survival (EFS) in patients >= 3 years of age with WHO grade IV/CNS WHO grade 4 and WHO grade III/CNS WHOgrade 3 diffuse high grade gliomas as well as diffuse high grade gliomas without a…
Develop a fast metabolic MRI protocol, based on DMI and 31P-MRSI at ultra-high field MRI, to investigate the Warburg effect and phospholipid metabolism in glioblastoma and to asses metabolic disruption in epilepsy.
This study has been transitioned to CTIS with ID 2022-501456-28-00 check the CTIS register for the current data. Primary objectives Part A:To test the non-inferiority, as evaluated by OS, of three courses of HDCT compared to focal RT plus…
To non-invasively measure metabolic alterations in GBM with 31P MRS at 7T and CEST MRI at 3T and 7T before and after radiotherapy (after the first session and after the whole treatment), and compare these results with Cx30 levels obtained from pre-…