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Prevention of renal and bladder damage in children with spina bifida by means of early injections with Botulinum-Toxin-A (Botox): a pilot study.

- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) prevent deterioration of the bladder and renal function?- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) decrease the need for an…

Non-invasive ultrasonic diagnosis of urinary Bladder Outlet Obstruction (BOO)

To study in a small group of male volunteers the feasibility of estimating urinary flow velocity and turbulence caused by obstruction using rf ultrasound. Subsequently, to compare in a group of patients eligible for TURP according to clinical…

Genetics of megacystis-microlon-intestinal hypoperistalsis syndrome

Identification of the underlying genes of MMIHS

Intermittent sacral neuromodulation for treatment of idiopathic overactive bladder in women

The aim is to elongate the service life of the implantable neurostimulator while achieving a minimal improvement of 50% of the symptoms of OAB.

Change in voiding pattern and quality of life in children with dysfunctional voiding who receive BoNT-A treatment: a prospective study.

To assess the change in voiding pattern and quality of life in children who receive BoNT-A treatment in a prospective setting.

Heart rate variability in patients with overactive bladder or stress urinary incontinence.

The goal of the study is to investigate the difference between heart rate variability in patients with overactive bladder and patients with stress incontinence without overactive bladder, and also the difference in heart rate variability with empty…

The role of GAG's in the pathology of interstitial cystitis (IC/PBS)

Our goal is to investigate the differences in the GAG-layer of patients with normal bladders and interstitial cystitis. We also want to evaluate the role of mast cells and heparanase in the pathogenesis of interstitial cystitis.

Non-invasive evaluation of urinary bladder contractility and urethral resistance after ProACT treatment of stress urinary incontinence in men: a pilot study.

The aim of the present study is to investigate the possibility of the use of non-invasive methods for the evaluation of bladder outlet obstruction after ProACT* device implantation by comparing non-invasive measurements with invasive measurements.…

A Pilot, Multicenter, Double-blind, Placebo-controlled, Dose-escalation Study of the
Safety and Efficacy of AGN-214868 in Patients with Idiopathic Overactive Bladder and
Urinary Incontinence

The objectives of this study are to evaluate the safety and efficacy of AGN-214868 compared with placebo in the treatment of patients with IOAB and urinary incontinence.The clinical hypotheses for this study are:• AGN-214868 has an acceptable safety…

An exploratory study to evaluate bladder contractions in the storage phase (non voiding activities) and related bladder sensation in healthy females and untreated females with Overactive Bladder (OAB) using high resolution and conventional urodynamics.

To identify objective parameters to characterize Non Voiding Activity (NVA) in healthy and OAB subjects using high resolution urodynamic assessmentNVA are changes of pressure in the bladder lumen. These changes are measured as detrusor pressure (…

MRI of the sacral plexus and sacral nerve roots in children with neurogenous bladder dysfunction with sacral or spinal anomalies

Gain insight in the anatomy and organisation of the sacral plexus in children with NB and congenital spinal or sacral anomalies. Possible findings can be compared with the results of the healthy subjects, in order to be able to relate findings to…

Is Uracyst effective to prevent or reduce acute radiation cystitis in patients who are treated with radiotherapy for gynaecologic malignancy?

The goal of the study is to find out whether micturition complaints are prevented or reducted by the bladder instillations with Uracyst and secondly if it has a positive effect on painscores and micturition related quality of life.

Effectiveness and cost-effectiveness of a smart urinary incontinence management solution for people with a profound intellectual disablity: an innovative client-centered care approach.

The aim of the project is to investigate whether the Nova contributes to cost-effective, client-oriented incontinence care for people with a profound disability, based on a cluster randomized study with a waiting list control group and a pragmatic…

Study of brain areas involved in the sensation of bladder filling in healthy females and untreated females with Overactive Bladder (OAB) using fMRI and water pressure urodynamics

Main objectives are to identify brain areas involved in sensation of bladder filling through fMRI during urodynamic measurements. Secondary goals are to assess the correlation between bladder filling and subjects* bladder sensations in combination…

Identification of muscle-invasive bladder cancer patients who will not benefit from neoadjuvant chemotherapy using circulating tumor cells.

Primary study objective is to prospectively assess whether the presence of CTCs in the peripheral blood of non-metastatic MIBC patients can identify patients with such a good prognosis not justifying neoadjuvant chemotherapy. Secondary study…