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Effectiveness of Eye Movement Desensitization and Reprocessing on Post Traumatic Stress Disorder in persons with mild intellectual disability and psychosis: A multiple baseline study

The main purpose of this study is to find out whether EMDR is a safe and effective treatment to reduce the symptoms of PTSD in people with mild intellectual disability and borderline intellectual functioning. In addition, it is expected to reduce…

Dynamic interactive Social Cognition Virtual Reality training (DiSCoVR): a pilot study

Primary ObjectiveIn preparation for a multicentre RCT we want to test the VR SCT for people with psychotic disorders in a feasibility study. We want to evaluate the feasibility and acceptability of VR SCT and improve the intervention protocol using…

The effect of Eye Movement Desensitization and Reprocessing on Psychosis: A multiple baseline study.

This study will examine the effectiveness of EMDR in the treatment of psychosis, in patients without PTSD. Primary objective of this study is a first exploration of the efficacy of EMDR in the reduction of psychotic symptoms, perceived power of…

The influence of Eye Movement treatment on imagery in psychosis

The objective of this study is to see wether the use of eye movement treatment (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger…

Effect of LY2165766 on Body Weight in Healthy Subjects

The purpose of the study is to investigate how well LY2165766 is tolerated, and to investigate whether LY2165766 administration is associated with body weight gain in comparison to placebo. Olanzapine is included in this study as a positive control…

Pilot study of the feasibility of research on the application of bright light as a means of restoring the sleep-wake rhythm in patients with schizophrenia admitted to the locked ward, and by that means alleviating their psychotic symptoms.

Objectives: To investigate if it is feasible to study giving light therapy to patients with schizophrenia or schizoaffective disorder who are admitted to a clinic. The secondary objectives are to investigate whether light therapy can also help to…

Using polygenic risk scoring in genetic counseling for mental illness: perception and added value (P-risk study)

The objective of this study is to assess the added value of polygenic risk scoring in psychiatric genetic counseling for patients with serious mental illness (SMI) and their family members. The secondary objective of this study is to explore…

Inference Based Approach, treatment for paranoia *
A replicated randomized single-case A-B-phase design

Primary objectives:Is IBA an effective treatment for patients with paranoia, that is, does IBA result in reduction of paranoia symptoms?Secondary objectives:Does insight improve after IBA treatment (i.e. insight in psychosis)?

Improving physical health and lifestyle behaviors in patients with serious mental illness: a cluster randomized controlled trial on the effectiveness of the nurse-led GILL eHealth intervention

Primary objective (after 1 year)- To evaluate the effectiveness of the nurse-led GILL eHealth intervention in patients with serious mental illnessSecundary objectives (after 1 year)- Improve metabolic syndrome severity- Improve fitness, physical…

Smoking cessation among people with severe mental illness: a study on effectiveness and implementation

Primary objectives (after 1 year): - to improve smoking cessation- to reduce number of smoked cigarettes Secondary objectives (after 1 year): - to reduce psychiatric symptoms such as depression, psychotic symptoms and anxiety- to improve physical…

Tackling defective epigenetic assembly in psychopathology:
Towards personalized intervention in Kleefstra syndrome

We aim to prevent or reverse developmental regression in patients with Kleefstra syndrome. We hypothesise that the regression we observed is the result of a psychotic disorder, which isnot properly recognised by clinicians and often not treated…