120 results
Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…
Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…
1. How does muscle overloading expressed by pain effect SB characteristics?2. What SB characteristics are associated with jaw-muscle pain?3. Are SB and psychological stress contributing factors for TMD pain?
PRIMARY OBJECTIVE1. To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of mechanically ventilated patientsSECONDARY OBJECTIVE1. To determine whether diaphragm muscle fiber weakness is part of a…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
-To assess the central chemosensitivity by an carbon dioxide rebreathing test-To assess mouth occlusion pressures during the carbon dioxide rebreathing test-To study the relation between these results and the results obtained with the MRI and…
The main objective of the study is to document cardiovascular dysfunction found in rheumatoid arthritis and gout patients using cardiac imaging techniques echocardiography and cardiac MRI.
Primary Objective: Our main goal is to contribute to the identification of an attentional profile of the paediatric TBI population, by analysing the quality and efficiency of alerting, orienting, executive and sustained attentional functioning. This…
The objectives of this study are:1) to quantify the muscle symptoms, muscle complaints, limitations in daily living, fatigue, mood disorders, and quality of life in patients with Brody's syndrome.2) determining the genetic background of Brody…
Because the pathophysiology of SSc is unknown, there is currently no treatment available to cure the disease itself, so only individual organ system complications are treated (7,8). Therefore, treatment is patient-specific and aimed at ameliorating…
This exploratorive study is performed to improve our understanding of possible etiologic factors and the relationships between foot mobility, intrinsic foot muscles and foot segment kinematics during gait for patients with sub-acute and chronic…
To determine whether nonspecific triggering of monocytes is associated with different epigenetic programming and expression of pro-inflammatory cytokines in clinically suspect arthralgia and in RA.
PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…
In this exploratory pilot study, we aim to investigate the role of immune activation in osteoporosis in HIV-infected patients on HAART with proven osteoporosis/ osteopenia in comparison to HIV-infected patients on HAART without osteoporosis/…
Measuring the brain activity in patients with chronic WAD and compare the results with those obtained in healthy volunteers. The goal of this research is to better understand the cause of chronic WAD and how to better treat the WAD-patients.
1) To compare (long-term) results of patients treated for Calcific Tendonitis with barbotage, versus patients treated for Calcific Tendonitis with other conservative standard-treatments2) An analysis of group characteristics and risk factors for CaT…
1) Determine the sarcomeric function in muscle fibers from FSHD patients2) Determine whether sarcomeric dysfunction is specific for FSHD or is part of a generalized pathology common to muscular dystrophies3) Test new therapeutic strategies (in vitro…
The aim of this project is to determine the possible use of biomarkers for non- or delayed-union in fractures of the diaphyseal femur and tibia.
To fully characterize skeletal muscle strength and endurance, phenotype and muscle fiber type-specific satellite cell content in frail elderly as compared to those elderly that do not classify as frail according to clinical criteria.
Previous studies [10] have proposed that cartilage degeneration due to obesity could be caused by changes in the joint kinematics during ADL that shifts the loading applied to cartilage. Such a shift may cause regions of cartilage to become newly (…