91 results
Primary Objective: to investigate the prevalence of bruxism and TMD in PD patients through objective measurements.Secondary Objectives: to identify factors associated with the presence of TMD or bruxism in a PD population.
The study aims to isolate and culture mesoangioblasts from muscle biopsies of two patient groups suffering from skeletal muscle atrophy to assess their potential for autologous muscle stem cell therapy. To relate this potential to the underlying…
This study has been transitioned to CTIS with ID 2023-510353-42-00 check the CTIS register for the current data. The purpose of this first-in-human study is to evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics…
Primary Objective:The primary objective of this study is to provide confirmatory data on the beneficial effect of 2.0 g/kg of Octagam 10% given every 4 weeks compared with placebo in subjects with active DM based on the percentage of responders at…
In this study we will assess whether the application of daily blood flow restriction during 2 weeks of bed rest will attenuate losses in skeletal muscle mass and strength. With measurements, before, during and after the bed rest period, we can…
We aim at investigating the role played by the innate and adaptive immune system and orienting a proper treatment. We will evaluate the percentage and features of circulating activated immune cells, cytokine production and gene expression profile…
To determine whether DUX4 can be detected in epithelial or stem cells isolated from midstream urine and/or buccal brush biopsies and/or skin punch biopsies of FSHD patients. Hereby we will assess whether any of these biomaterials can be used as an…
Primary Objectives: 1a. To investigate whether differences exist in training response after a 12-week combined endurance- and resistance training program between statin users with and without muscle complaints and a control group (non-statin users).…
(I) Compare shoulder loads estimated with musculoskeletal simulations, stability and associated muscular effort of subjects with FSHD and healthy controls during the performance of standardized upper extremity tasks with and without an arm support…
Primary Objective: Development of an DTI sequence for muscle fibre integrity assessment of the swallowing musclesSecondary Objective(s): 1. Reproducibility assessment of the muscle fibre integrity assessment with DTI in healthy volunteers: (a)…
to investigate the role of regulatory T cells in response to heat shock proteins in muscle and peripheral blood of patients with juvenile dermatomyositis. To identify patterns in T-cell responses and cytokineprofiles, in relation with clinical…