40 results
The primary objective is to elucidate whether there is a difference in the outcome of health parameters between IVF children who as an embryo were cultured in two different culture media. As secondary objectives we will investigate how the health…
The aim of this pilot study is to assess the effect of low intensity mastication training in patients with a mitochondrial disease on masticatory performance, efficacy, endurance, bite force and the feasibility of this training .
Primary:To estimate the treatment effects of vildagliptin 50 mg PO BID on 24h weighted-mean glucose (WMG), using CGM and plasma glucose, collected at the end of a two-week treatment period.Secondary:1) To estimate the treatment effects of…
The main objective of this study is to test whether cognitive behaviour therapy delivered by internet has a significant effect on fatigue in patients with type 1 diabetes en whether this effect is sustained during a follow-up period of six months.…
2.1 Primary Objectives: 1) To test the feasibility of the six minute assisted leg and arm cycling test in patients aged 6-18 years with Duchenne muscular dystrophy (DMD), Beckers muscular dystrophy (BMD), Limb Girdle muscular dystrophy (LGMD),…
Goal of this study is to investigate whether hepatic steatosis can be found in adolescents born SGA who have had prolonged GH treatment because of short stature. A possible relationship between hepatic steatosis and insulin sensitivity, adipose…
To assess the difference in efficacy of pancreatic enzymes in a self-dosage regimen after extensive patient-education in comparison to the standard treatment for patients with EPI.
This trial will determine the relative incidence of CV outcomes compared to placebo forthe TZD class as a whole, rosiglitazone (RSG), and pioglitazone (PIO) when added to thetherapeutic regimen of a person with type 2 diabetes who has additional…
To evaluate the long-term safety and efficacy of BMN 110 administration at 2.0 mg/kg/qw and 2.0 mg/kg/qow in patients with MPS IVA.
Primary objective:To observe the effect of gastric bypass surgery on household members and partners who live together with the patient on body mass index (measured as weight/height²) in the first year following bariatric surgery compared to family…
Primary objective of the study is•To investigate the change of Urinary Albumin-to-Creatinine ratio (UCAR) after 90 days treatment Secondary objectives of the study are•To assess safety and tolerability of these doses by assessing the effects on…
The primary aim of this study is to assess the impact of prolonged walking on fluid- and electrolyte balance in 32 patients with T2DM, compared with a matched group of 32 healthy control subjects, and 32 patients with T1DM, during the Nijmegen Four…
-Determination of the effects of an exercise program on ectopic fat accumulation in heart, liver and skeletal muscle-To assess the relationship between metabolic and inflammatory parameters with changes in MRI outcome-To assess the differences in…
Primary objectives: * Continuous glucose values with registration of carbohydrate intake, vital signs, physical activity, emotional stress and insulin delivery. The data will be used to develop forecasting algorithms for glucose levels on a time…
The objective of the study is the assessment of the effect of the use of the 'free style navigator continuous monitoring system' on the glucose variability in patients with type 1 diabetes mellitus. This assessment is combined with the…
Primary Objective:To identify suitable markers and their time course in order to better understand BEP chemotherapy induced oxidative stress in a minimally invasive manner.Secondary Objective:To measure the effect of chemotherapy on the elasticity…
The main objective of this study is to determine the role of glycaemic control in diabetes mellitus in the occurrence of acetylsalicylic acid resistance, the secondary objective is to determine the effect of increased dosing on acetylsalicylic acid…
- To systematically determine metabolic adverse affects of RA patients, who (chronically) use GCs in order to reduce disease activity, compared to RA patients who don*t use GCs.- To study the relation between disease activity, treatment, and…
This study-protocol is directed at the comparison of two accepted management strategies at both ends of the current treatment-spectrum of moderate hypoglycemia in 'high risk' newborns: an intensive treatment versus an expectant monitoring…
To investigate the association between two polymorphisms of the HTR2C gene (5-HT2c-receptor gene) (3813929 C/T and rs1414334: C>G) and metabolic adverse drug reactions in starters with mirtazapine (5-HT2C-receptor antagonist) versus…