21 results
We aim to measure the vitamin D status (25(OH)D) and prevalence of vitamin D deficiency in Western and non-Western infants and toddlers aged six months to four years in the Netherlands. We will assess the cross sectional association between vitamin…
Aims of the Study: Our main aim is to characterize cortical brain plasticity in individuals with impaired fasting glucose (IFG) and patients with type II diabetes mellitus (DM2) as compared with age-, gender-, and IQ-matched healthy controls(HC).•…
Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia
To determine: 1) the incidence of type 2 diabetes mellitus in FCHL patients, normolipidemic relatives and their spouses2) the incidence of cardiovascular disease in FCHL patients, normolipidemic relatives and their spouses3) the prevalence of CESD…
1. Does general anesthesia affect autonomic sympathetic control of coronary blood flow in healthy subjects?2. Does acute inhibition of autonomic sympathetic innervation by means of a thoracic epidural or a thoracic sympathectomy additionally impair…
To determine whether a difference in resilience of inflammatory tone between healthy and prediabetic males can be identified with whole blood ex vivo LPS stimulation.
We hypothesize that impaired insulin uptake into skeletal muscle interstitium (thus decreased transendothelial transport of insulin) is impaired in patients with type 2 diabetes mellitus. This hypothesis will be addressed in the present study.
a) To investigate the differences in adipokines and inflammatory markers between obese and normal weight children; b) to study these differences over age, and c) to correlate adipokine/inflammatory marker profiles to clinical parameters for obesity…
To answer the question if structural changes of the brain and impairments of cognitive functioning in type 1 diabetes are related to the presence of microvascular disease we will· Compare brain structure (brain volume, white matter lesions) and…
Primary objective:To compare the mean absolute glucose change in postoperative older patients with and without a delirium.Secondary objectives:1. To compare the mean glucose concentration and glucose variability in postoperative older patients with…
The search for correlations between components of the diet and the group has experienced a hip fracture. These findings are compared with healthy elderly. The results can contribute to nutrition -focused interventions in future studies .
the first objective of this study is to quantify the impact of chronic Q-fever or QFS on work status and psychosocial functioning. Secondly, we will identify factors that are associated with these limitations, to determine which subgroups of…
To investigate the effect of oral curcumin supplementation on different clinical parameters and the gut microbiota composition in patients with diabetes type II, inflammatory bowel disorders (both ulcerative colitis and Crohn*s disease in remission…
Primary Aim: We aim to determine markers for NOX2-mediated insulin-independent glucose uptake signalling pathways, mitochondrial function, myokine secretion both at rest and after a bout of acute exercise in individuals with T1DM and healthy…
The primary objective of this study is to determine the variation in postprandial glucose responses to the same meals/food products and how this relates to the variation in postprandial glucose responses over a 9-week fully controlled dietary…
To perform a patient satisfaction study on the Equil patch pump in T1DM patients that currently already use CSII in combination with CGM or Flash glucose monitoring.
Primary Objective: Main aim of the study is to investigate in detail the differences in gene expression, body composition, muscle function and muscle metabolism in colon cancer patients compared to controls. Secondary objectives:Secondary aim of the…
This protocol involves studies that aim at:1. A better understanding of sensory perception and eating behaviour2. Validation of newly developed sensory and behavioural methods3. To determine the effect of fat, sugar and/or salt reduction on sensory…
The aim of this research is twofold:1) Determining the functionality of the oxygen sensor in the neck (the glomus body or *carotid body* during the administration of glucose and insulin, a so-called euglycemic hyperinsular clamp.2) Validating a new…
The primary objective is to test the feasibility of EGP quantification in adult GSDIa patients by stable isotopes after a single oral D-[6,6-2H2]glucose dose. Secondary objectives are to compare EGP assessed by a single oral D-[6,6-2H2]glucose dose…
Primary objective: Develop a completely novel and non-invasive method to map body metabolism in humans based on DMI on a 7T MRI scanner.Secondary objectives: To demonstrate proof of concept by measuring (1) hepatic glucose metabolism and (2) de…