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Interindividual variability in brain vulnerability to elevated blood phenylalanine concentrations in PKU patients - pilot study on amino acid transport in fibroblasts as a representative of the blood-brain barrier

To further characterize the transport of phenylalanine and other large neutral amino acids across the blood-brain barrier in PKU patients with high and low brain vulnerability to elevated blood phenylalanine concentrations, we will investigate…

The fate of incomplete amino acid metabolism in type 2 diabetes

1. to determine whether the oxidation of BCAA (leucine) is impaired in patients with T2DM and in humans at risk to develop T2DM (first degree relatives). 2. to investigate whether an altered leucine oxidation in muscle is associated with insulin…

The impact of short-term forearm immobilization on forearm muscle glucose and amino acid metabolism of volunteers with or without type 2 diabetes

To assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics of individuals with T2D compared with a control group with normoglycaemia.

Protein oxidation in stable renal transplant patients measured with a breath test

To study whether stable renal transplant patients show higher protein oxidation measured with the 13C-breath test as compared to healthy kidney donor subjects.