38 results
To unravel the cause(s) of the FH phenotype in patients with no mutations in well-established lipid genes (LDLR, APOB, PCSK9).
The primary objective is to elucidate whether there is a difference in the outcome of health parameters between IVF children who as an embryo were cultured in two different culture media. As secondary objectives we will investigate how the health…
Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia
To determine: 1) the incidence of type 2 diabetes mellitus in FCHL patients, normolipidemic relatives and their spouses2) the incidence of cardiovascular disease in FCHL patients, normolipidemic relatives and their spouses3) the prevalence of CESD…
Hypertension is characterized by vascular remodelling and endothelial dysfunction. Sphingolipids such as ceramide and sphingosine-1-phosphate may play an important role in regulation of vascular contractility and tonus. In this study the altered…
To obtain human fibroblasts from extreme dyslipidemia patients or patients with premature atherosclerosis to study cholesterol metabolism.
The purpose of the current study is to evaluate the difference in TICE in FHBL-patients as compared to unaffected controls, according to the previously developed stable isotope method with minor modifications (METC 10/092). This way we can prove the…
Aim of this study is to acquire more insight in the relation between risk factors for cardiovascular disease and type 2 diabetes and anthropometric measures such as BMI, waist circumference and body fat percentage and compare the results between the…
To assess the difference in efficacy of pancreatic enzymes in a self-dosage regimen after extensive patient-education in comparison to the standard treatment for patients with EPI.
The purpose of the current study is to evaluate the difference in TICE in FHBL-patients as compared to unaffected controls, according to the previously developed stable isotope method with minor modifications (METC 10/092). This way we can prove the…
To investigate the frequency and the biology of the metabolic syndrome in childhood cancer survivors in order to find risk factors for cerebro- and cardiovascular diseases and to design preventive intervention strategies in indicated risk groups
We would like to evaluate the beneficial effects of fibrate treatment on muscle mitochondrial and cardiac function in patients with NLSDM.
In this study, we will evaluate if these HME subjects are characterized by impaired postprandial lipid clearance compared to otherwise healthy control subjects
To characterize the dyslipidemias and their consequences in carriers of mutations in glycosylation genes.
The aim of the present research proposal is to metabolically phenotype endurance trained athletes, lean and obese sedentary and type 2 diabetic individuals with the following objectives:(1) To assess metabolic flexibility as measured by a euglycemic…
The most important objectives of this study:1) examine the bacterial translocation as a consequence of elevated intestinal permeability in the morbid obese compared to controls, and to proove this is causes an inflammatory status predisposing IR/…
This study will evaluate the effect of approximately 10 years of pravastatin treatment on IMT in young adults with FH. Furthermore, safety parameters and psychological aspects with respect to early treatment initiation will be investigated.
Following the participants three more years will enable us to get a better overview of the consequences of the screening with regard to treatment, health, lifestyle modifications and illness perception with regard to obesity. Primary Objective: • To…
Assess the prevalence of the metabolic syndrome and quality of life in patients with Addison*s disease treated with low dose GRT. Study the relation between GRT, QoL and glucocorticoid receptor polymorphisms
1. To investigate the causal relationships between atherosclerotic disease risk and existing, long-term cyanotic heart disease. 2. To differentiate these causal relationships according to each of the assessed risk factors and their relationship with…
1) To asses heparin-induced LPL release curves in patients with the Mets 2) To determine differences in gene expression of LPL, GPIHB1 and ANGPTL4 in muscle and adipose tissue of patients with the MetS compared to health controls3) To determine…