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Renal Nerve Stimulation and Renal Denervation in Patients with Sympathetic Ventricular Arrhythmias

This study will investigate the effects of renal nerve stimulation before and after percutaneous transluminal renal denervation on cardiac excitable properties including induction of ventricular tachy-arrhythmias before and after renal denervation…

A multicenter, randomized, partially-blinded, Phase IIb dose-finding study on ovarian function, vaginal bleeding pattern, and pharmacokinetics associated with the use of combined vaginal rings releasing 17*-estradiol plus three different doses of either nomegestrol acetate or etonogestrel in healthy women aged 18-35 years;

The main objective of the trial is to identify at least one NGR that will demonstrate all of the following:1. Inhibition of ovulation2. Cycle control that is non-inferior to NuvaRing®, as judged by the incidence ofBTB-S during Treatment Cycle 3. The…

A Randomized, 4-Arm, Placebo-Controlled Phase 2 Trial of AMG 386 in Combination with Bevacizumab and Paclitaxel or AMG386 plus Paclitaxel as First-Line Therapy in Subjects with Her2-Negative, Metastatic or Locally Recurrent Breast Cancer.

To estimate the treatment effect as measured by progression free survival(PFS) of subjects receiving AMG 386 (at 2 doses) in combination with paclitaxel + bevacizumabrelative to paclitaxel + bevacizumab + placebo.

Biodegradable polyurethane foam modified with 55% polyethyleneglycol as a local hemostatic agent, a pilot study.

Goal of this study is to asses the feasibility of polyurethane foam as a local hemostatic agents in sockets after dental extraction. The assessment will take place in a small number of patients. After the pilot study, a large study will be…

A Phase I Study of Oral Topotecan in Subjects with Cancer and
Impaired Renal Function

Primary• To determine the safety profile of oral topotecan in subjects with cancer andmildly moderately or severely impaired renal function (Groups C, D and E) compared to subjects with cancerwhose renal function is normal and who have received…

validity, measurement feasibility and reliability in geriatric outpatients

To assess the clinical feasibility, reliability and validity of the combined barocontrol PPG-NIRS-ECG monitor.

Safety and preliminary efficacy of Alkaline Phosphatase in severely burned patients

The primary objective of this study (MAP4B-safety) is to assess the safety of the application of the therapeutic product Alkaline Phosphatase (AP) in severely burned patients admitted to the intensive care unit. Secondary objectives are to assess…

The CanISleepinMS Study:
Effect of cannabidiol (CBD) on sleep quality in patients with multiple sclerosis, a series of 15 randomised, placebo-controlled N-of-1 trials

This study has been transitioned to CTIS with ID 2024-518280-35-00 check the CTIS register for the current data. To investigate the effect of CBD on MS patients with impaired sleep quality.

A partially-blinded, active-controlled, multicenter, randomized study evaluating efficacy, safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD) of an anti-CD40 monoclonal antibody, CFZ533, in de novo and maintenance kidney transplant recipients (CIRRUS I, CCFZ553A2201)

Primary Objective(s) (Cohort 1):* To demonstrate that CFZ533 600 mg and/or 300 mg bi-weekly (Q2W), subcutaneous (SC), is non-inferior to a tacrolimus-based regimen with respect to the proportion of patients who experience composite efficacy failure…

A Long-Term Extension of the ARGX-117-2002 Trial to Evaluate the Long-term Safety and Tolerabillity, Efficacy, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of ARGX-117 in Adults with Multifocal Motor Neuropathy

This study has been transitioned to CTIS with ID 2023-507052-69-00 check the CTIS register for the current data. To evaluate the long-term safety and tolerability of ARGX-117 in adult participants with MMN

A PHASE 2 STUDY OF ALX148 IN COMBINATION WITH PEMBROLIZUMAB AND CHEMOTHERAPY IN PATIENTS WITH ADVANCED HEAD AND NECK SQUAMOUS CELL CARCINOMA (ASPEN-04)

This study has been transitioned to CTIS with ID 2023-508342-17-00 check the CTIS register for the current data. Primary Objective• To assess the effect of ALX148 + pembrolizumab + 5FU + platinum on 12-month overall survival (OS) rate and objective…

Visualizing beta cells after Intrahepatic Islet of Langerhans Transplantation

Primary Objective: Compare the uptake of 68Ga-NODAGA-exendin-4 in the liver between T1D patients with functional islet grafts (C-peptide > 0.8 nmol/L after mixed meal stimulation test and relevant laboratory parameters as HbA1C and exogenous…

A Phase II, prospective, intra-patient randomised controlled, multicentre study to evaluate the safety and efficacy of an autologous bio-engineered dermo-epidermal skin substitute (EHSG-KF) for the treatment of full thickness skin defects in adults and children in comparison to autologous split-thickness skin grafts (STSG)

This study has been transitioned to CTIS with ID 2024-512190-27-00 check the CTIS register for the current data. To evaluate the efficacy and safety of EHSG-KF in comparison to STSG (unmeshed or meshed up to 1:3) in adults and children with large…

A randomised, controlled, double-blind, parallel group, multi-country study to investigate the effects of an infant formula containing partially hydrolysed proteins on growth, safety, and tolerance in healthy term infants

To investigate the effects of a partially hydrolysed protein based infant formula (pHPformula) in healthy term infants until 17 weeks of age on growth, blood parameters, safety,and gastro intestinal tolerance compared to standard infant formula.…

Explorative study: serious games rehabilitation programme to manage gait and balance disorders in patients with Parkinson's disease

The primary objective is to evaluate the efficacy of the serious game *Toap Run* on gait and balance outcomes in patients with PD. Secondary objectives include assessing the effects of the game on disease symptoms, spatiotemporal gait parameter and…