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Characterization and localization of microstructural changes in brain tissue in Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)

• To increase the sensitivity of the current MRI methods for detecting the changes caused by NPSLE through the scans made on the 7 Tesla scanner, since the higher field strength will lead to a higher signal to noise ratio and higher resolution. • To…

Back to the beginning * the Amylon study: Serum amylase, urinary amylase and serum lipase for diagnosing acute pancreatitis

to investigate the course of the pancreatic enzymes (serum amylase, serum lipase and urinary amylase) related to the course and stage of acute pancreatitis and thereby calculating the diagnostic accuracy of each pancreatic enzyme for acute…

Immunological phenotype of asthma severity
(iPhase)

Our main objective is the characterization and comparison of interactions/ phenotype differences in DCs, Th cells and ILC2s obtained from asthma patients with controlled, partly controlled and uncontrolled clinical symptoms and healthy controls.

Calibration of non-invasive measurement of mitochondrial oxygenation in healthy volunteers

Calibration of the mitochondrial oxygen tension technique in the human skin

Observational multi-center, prospective study to develop a novel multi-parametric diagnostic model for hospitalized patients and patients on the Emergency Department presenting with lower respiratory tract infections and/ or sepsis.

To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.

BIOmarkers for cogNitive Impairment due to Cerebral Amyloid Angiopathy (BIONIC)

[1] To develop robust assays for quantification of novel CSF/blood biomarkers of CAA.[2] To determine the contribution of CAA to cognitive decline in dementia and ICH patients, using CAA-specific biomarkers

Evaluating blood biomarkers from healthy controls and patients with
age*related disease: Alzheimer*s disease

The primary objective is to evaluate plasma levels of A*1*42/A*1*40 ratio, A*1*40, A*1*42, neurofilament light (NFL), t*tau and anti*tau antibodies as disease*specific markers for AD. The secondary objective is to measure biological age parameters (…

: Long-term follow up of growth and bone mineralization of former preterm infants

To determine whether increased calcium and phosphate intake (2005 group) resulted in improved Bone Mineral Content (BMC) and Bone Mineral Density (BMD) compared to the group with less calcium and phosphate intake (2004 group) at the age of 8-10…

The development of an observation assessment tool concerning mastication in children with cerebral palsy.

1. Discribe the normal development of mastication in healthy children aged between 6 and 48 months by using the Mastication Observation and Evaluation (MOE). Which oral motor behaviours occurs?2. Determine the differences in mastication between…

Airway obstruction in children with congenital mandibular hypoplasia.

Primary objectives:1a. To determine the severity and course of obstructive sleep apnea in children with congenital mandibular hypoplasia (both isolated and syndromal).1b. To determine the growth pattern of the lower face in relation to the upper…

FunctiOnal lIver MicrocIrculation measured by SorbiTol and Indocyaninegreen plasma Clearance, the OptIMISTIC- study.

Objectives: The objective of the study is to observe the sorbitol clearance and compare this to ICG clearance in different circumstances of normal and compromised liver blood flow.

A single-centre prospective observational study into development of microcirculatory alterations and response to therapy in adult critically ill patients

The primary objective of this study is to identify in what manner micro- and macro hemodynamic parameters responds to critical illness and therapy, and to determine how this interaction is related to different states of organ dysfunction (heart,…

fNIRS in children with traumatic brain injury - relation with outcome

This study is part of a prospective cohort study in the University Medical Center Groningen aimed at the determination of prognostic factors for outcome of children with TBI. The study is a pilot study to determine the value of fNIRs for detection…

Hemoglobin Assessment: Precision and Practicability Evaluated in the Netherlands

With this study, we aim to evaluate precision and practicability of three new measurements for (venous) Hb, as compared with the present standard.* Precision will be studied as sensitivity and specificity of the measurements for a venous Hb under…

Dynamics of the human yolk sac in the first trimester of pregnancy.

To show that the human secondary yolk sac follows a dynamic pattern during the day by the investigation of:1.) size and volume of the human secondary yolk sac at several time points during one day2.) the relationship between size and volume of the…

Aeonose and Complex Regional Pain Syndrome

The goal of the study is to investigate whether the Aeonose can detect a CRPS-specific pattern of volatile organic compounds in the exhaled air of patients with CRPS.

Fatigue after prophylactic cranial irradiation in stage I-III small cell lung cancer patients: is there a substrate on functional magnetic resonance imaging of the brain?

To asses the effect of PCI on the brain with functional MRI (fMRI) and diffusion tensor imaging (DTI)-MRI and assess whether there is a correlation with patient-experienced fatigue.

Distal radioulnar joint cartilage quantification at ultra high field 7T MRI

The primary objective is to determine feasibility of DRUJ cartilage quantification on ultra high field strength 7T MRI by imaging healthy volunteers and OA patients. Feasibility means succesfull imaging DRUJ cartilage for all subjects. The two…

Speech recognition and temporal resolution in listeners with unilateral hearing loss; intra- and inter-individual differences

we aim to enhance insight in the specific influence of cochlear hearing loss on auditory processing and speech. We expect that the results for the normal ears of the unilateral hearing loss listeners is comparable to the results for normal hearing…

A multicenter prospective study of biochemical profiles of monoamine-producing tumors: utility
for diagnosis and determinants of clinical presentation. (The PMT study)

Primary objective:to identify new and improved disease biomarkers and establish the biochemical and molecular basis for variations in the clinical presentation of the different groups of tumors.Secondary objectives:• compare the diagnostic utility…