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Maternal pharmacokinetics and pharmacodynamics of nicardipine (iv) during treatment of severe hypertension in pregnancy.

Our aim is to determine a Pharmacokinetic/Pharmacodynamic (PkPd) based dosing model for nicardipine used for treatment of severe hypertension in preeclamptic patients. The model is based upon determination of maternal, fetal and neonatal plasma…

Imaging the neurodevelopmental consequences of intrauterine exposure to Antipsychotics and Lithium

1. To investigate whether children exposed to lithium or antipsychotics in utero have subtle structural brain differences compared to non-exposed children at the age of 8-14 years old (primary objective).2. To investigate whether children exposed to…