7 results
Primary Objectives:- Determine the effect of pulmonary vasodilatation on indexed cardiac output during simulated exercise.- Characterization of structural properties of small pulmonary arteries.Secondary Objectives: - Investigate the effect of…
1. To characterize and compare RV myocardial structure, contraction patterns, and functional capacity of (A) PH patients (group 1 or 4, the latter are to be inoperable), (B) patients with pressure overloaded RV due to CHD and (C) healthy controls. 2…
Therefore, the aim of our study is to determine whether and when changes in sympathetic signalling in the RV of IPAH patients occur, using [11C]-HED and [11C]-CGP-12177 PET imaging.
The primary objective of this study is to investigate the role of vascular cells, with focus on pulmonary arterial endothelial cells (PAEC), in the development and pathogenesis of extensive thromboembolisms as observed in CTEPH.
We hypothesize that the development of a follow-up program of unaffected mutation carriers will lead to early identification of disease and in the development of strategies to prevent the development of disease and successful treatment.
Assess BMP10 secretion in patients with pulmonary arterial hypertension and its effect on right ventricular adaptation to pressure overload.
We aim to identify if pediatric PAH patients have increased plasma IL-1β and IL-18 compared to control participants, as well as increased caspase-1 cleavage and NLRP3, IL-1β and IL-18 mRNA expression in PBMCs, reflective of inflammasome activation.…