39 results
The primary objective is to validate a previously established prognostic instrument in the form of an algorithm (flowchart) in patients that present with AECOPD to the department of emergency medicine for classifying for out- or inpatient treatment…
The main objective of this study is to assess the ability of a wearable measurement system, the Hexoskin smart shirt, to detect and quantify dynamic hyperinflation. Secondary objectives are to determine the optimal measurement procedure and to…
To compare a ventilation strategy using higher levels of PEEP with recruitment maneuvers with one using lower levels of PEEP without recruitment maneuvers in obese patients at an intermediate-to-high risk for PPCs.We hypothesize that an intra-…
The present study aims at comparing the post-operative lung injury of a lung*protective mechanical ventilation strategy (with the use of higher levels of PEEP and intra*operative recruitment maneuvers) with conventional mechanical ventilation (lower…
* To define the characteristics of children with severe asthma and severe pre school wheeze in terms of clinical features, physiology and biomarker profiles and to compare these with patients with mild-moderate asthma and wheeze* To repeat the…
We hypothesize that an electronic nose can discriminate between the exhaled breath of patients with established pulmonary sarcoidosis from healthy controls Secondly, we hypothesize that an electronic nose can discriminate between different stages of…
RECODE aims to assess the (cost) effectiveness of an ICT-supported, integrated, multidisciplinary two-year treatment of COPD in primary care as compared to usual care.
Primary Objective: Which physiological impairments and complaints are present during activities of daily living in patients with mild COPD? Secondary Objective(s): Are physiological impairments and complaints during activities of daily living…
To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis
Questions/aimsTo study the effects of dynamic hyperinflation on pulmonary hemodynamics and right and left ventricular function we formulated the following questions.Do COPD patients with dynamic hyperinflation have a more impaired response of stroke…
First Objective: Is the percentage of subjects that dynamic hyperinflate during activities of daily living larger in patients with mild COPD than in healthy controls?Second Objective(s): Will dynamic hyperinflation induced by activities of daily…
To investigate the efficacy of repeated daily doses of nebulised RPL554 (0.018 mg/kg) by assessing the effect on FEV1 at day 1, 3 and 6 after daily inhaled doses of nebulised RPL554 0.018 mg/kg (6X) in 16 allergic asthmatics.
Major objectives:- To determine the role of small airways abnormalities in the clinical manifestations of asthma;- To evaluate which (combination of) clinical methods best assesses the abnormalities of small airways and large airways disease in…
The aim of this study is to identify direct markers of muscle and adipose tissue hypoxia in COPD and CHF patients in relation to the altered muscle oxidative phenotype and the putative mediators HIF-1α and PPARs/PGC-1. Insight in the underlying…
Observational part on respiratory parametersThe primary objective of this study is to study the effect of hypothermia and rewarming on P/F ratio as a measure of oxygenation and on end tidal CO2 as a measure of ventilation during mechanical…
To establish platelet function and primary hemostasis during lung transplantation
Primary study objectiveTo investigate the prevalence of asthma in children up to 7 years of age with atopic dermatitis in infancy who received either Nutrilon Pepti with synbiotics or Nutrilon Pepti without synbiotics during 12 weeks in their first…
To evaluate the effectiveness of the Chartis System in selecting subjects with heterogeneous emphysema who will achieve Lung Volume Reduction from Endobronchial Valve therapy.
Objective: To investigate posture dependent small airway obstruction in subjects with obesity. To study the capacity of FOT as a measurement tool for small airways obstruction.
1a. To compare metabolic response during ADL between patients with moderate to severe COPD and healthy age-matched control subjects.1b. To compare symptom Borg scores for dyspnoea and fatigue and heart rate during ADL between patients with moderate…