37 results
The primary objective is to validate a previously established prognostic instrument in the form of an algorithm (flowchart) in patients that present with AECOPD to the department of emergency medicine for classifying for out- or inpatient treatment…
The main objective of this study is to assess the ability of a wearable measurement system, the Hexoskin smart shirt, to detect and quantify dynamic hyperinflation. Secondary objectives are to determine the optimal measurement procedure and to…
Major objectives:- To determine the role of small airways abnormalities in the clinical manifestations of asthma;- To evaluate which (combination of) clinical methods best assesses the abnormalities of small airways and large airways disease in…
PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…
* To define the characteristics of children with severe asthma and severe pre school wheeze in terms of clinical features, physiology and biomarker profiles and to compare these with patients with mild-moderate asthma and wheeze* To repeat the…
We hypothesize that an electronic nose can discriminate between the exhaled breath of patients with established pulmonary sarcoidosis from healthy controls Secondly, we hypothesize that an electronic nose can discriminate between different stages of…
RECODE aims to assess the (cost) effectiveness of an ICT-supported, integrated, multidisciplinary two-year treatment of COPD in primary care as compared to usual care.
Questions/aimsTo study the effects of dynamic hyperinflation on pulmonary hemodynamics and right and left ventricular function we formulated the following questions.Do COPD patients with dynamic hyperinflation have a more impaired response of stroke…
To investigate the efficacy of repeated daily doses of nebulised RPL554 (0.018 mg/kg) by assessing the effect on FEV1 at day 1, 3 and 6 after daily inhaled doses of nebulised RPL554 0.018 mg/kg (6X) in 16 allergic asthmatics.
To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis
Primary Objective: Which physiological impairments and complaints are present during activities of daily living in patients with mild COPD? Secondary Objective(s): Are physiological impairments and complaints during activities of daily living…
First Objective: Is the percentage of subjects that dynamic hyperinflate during activities of daily living larger in patients with mild COPD than in healthy controls?Second Objective(s): Will dynamic hyperinflation induced by activities of daily…
The objective is to investigate whether environmental exposure to livestock farm emissions in the Netherlands poses a health risk among neighbouring residents.
* To define the characteristics of patients with severe asthma in terms of clinical features, physiology and biomarker profiles and to compare these with patients with mild-moderate asthma, and healthy controls* To repeat the measurement of clinical…
The AlphaCore* is currently being used in some hospitalised COPD subjects, as adjunctive treatment to regular care. This use is conform CE and is showing diminished breathlessness in some subjects. For further investigation of these results, this…
Primary study objectiveTo investigate the prevalence of asthma in children up to 7 years of age with atopic dermatitis in infancy who received either Nutrilon Pepti with synbiotics or Nutrilon Pepti without synbiotics during 12 weeks in their first…
To evaluate the effectiveness of the Chartis System in selecting subjects with heterogeneous emphysema who will achieve Lung Volume Reduction from Endobronchial Valve therapy.
Observational part on respiratory parametersThe primary objective of this study is to study the effect of hypothermia and rewarming on P/F ratio as a measure of oxygenation and on end tidal CO2 as a measure of ventilation during mechanical…
The aim of this study is to identify direct markers of muscle and adipose tissue hypoxia in COPD and CHF patients in relation to the altered muscle oxidative phenotype and the putative mediators HIF-1α and PPARs/PGC-1. Insight in the underlying…
The objective of the standardized protocol is optimalizing the accuracy of the diagnosis (all-cause pneumonia, or serotype-specific pneumonia) during the 13-valent pneumococcal vaccin (13vPnC) study which will be performed in 2008. Additionaly, the…