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the Application of an Electronic Nose in the Early detection of Aspergillosis II

1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…

A multi-center, prospective, blinded validation study to assess the accuracy of a host-response based diagnostics for distinguishing between bacterIal and viral etiology in pediatric patients with lower respiratory tract infections and fever without source

To externally validate the accuracy of a host-response based diagnostics for differentiating between bacterial and viral etiology in pediatric patients aged 2 to 60 months with LRTI or FWS.

Observational multi-center, prospective study to develop a novel multi-parametric diagnostic model for hospitalized patients and patients on the Emergency Department presenting with lower respiratory tract infections and/ or sepsis.

To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.

CRP-POCT in suspected airway infected patients in the long-term care facility

The main objective is to investigate the additional value of CRP-POCT (C-reactive protein point-of-care-test) testing in patients suspected of airway infections in long-term care facilities.

Pulmonary function after mechanical ventilation for respiratory syncytial virus induced respiratory failure in infancy

Primary Objective: *To study differences in pulmonary function (i.e. increased airway resistance) one year after hospitalisation for RSV LRTD between mechanically ventilated and non-ventilated infantsSecondary Objectives: *To study…

Ventilator induced lung injury by mechanical ventilation in children with respiratory syncytial virus infection.

The aim of this study is to compare the time course of cytokines (markers for inflammation) in the following 3 groups: RSV-positive, ventilated patients; RSV-positive, non-ventilated patients and RSV-negative, ventilated patients. The main…

Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children

Aims: 1. To optimize the diagnosis of M. pneumoniae infections by discriminating between colonization and symptomatic infection using quantitative PCR. 2. To study the role of host factors (age, and bacterial and viral co-infection) on infection by…

The Genetic variability in the host response to community-acquired pneumonia

To determine the genetic risk of susceptibility to, or severity of community-acquired pneumonia by comparing the interpersonal genetic variation of the host immune response of patients with community-acquired pneumonia to healthy controls and by…

*Microbiological evaluation of BAL fluid from patients with nosocomial Pulmonary Aspiration Syndrome compared to BAL fluid from hospitalized patients undergoing inspection bronchoscopy. A pilot study.*

Validation of microbiological analyses of BAL (broncho alveolar lavage) fluid in patients suspected of nosocomial bacterial aspiration pneumonia.

The role of innate immunity in the pathogenesis of acute respiratory syncytial virus lower respiratory tract infection:
Repeated measurements of nasopharyngeal type 1 interferon levels in RSV infections

To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…

Point-of-Care C-reactive protein to assist in primary care management of children with lower respiratory tract infection

Analyse costs and effects of point of care (POC) C-reactive protein (CRP) measurement in children with non-severe lower respiratory tract infection (LRTI) in primary care.

Recurrent respiratory tract infections (RRTI) in the elderly: from phenotypic and immunological characterizaton to a mechanistic unravelling of a potential primary immunodeficiency (PID).

The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…

Preliminary effectiveness and feasibility of two pre-operative Inspiratory Muscle Training (IMT) interventions in patients undergoing oesophageal resection

Main objective is to examine the preliminary effectiveness of preoperative IMT high-intensity in patients undergoing oesophagus resection on postoperative pulmonary complications, inspiratory muscle strength/endurance and IC stay compared to…

Venturius study
Epidemiology, genetics and immunology of viral lower respiratory tract infections in children.

Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.

the Application of an Electronic Nose in the Early detection of ASpergillosis

to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls

Genomics to combat Resistance against Antibiotics in Community-acquired LRTI in Europe: GRACE Workpackage 9: Study on the aetiology, diagnosis and prognosis of lower respiratory tract infections in primary care

Within the observational study WP9, there will be 3 substudies. First the microbiological aetiology of LRTI will be studied by comparing test results in 3000 healthy controls to findings in 3000 adults with LRTI. Bacterial resistance rates will be…

Effect of Coxiella burnetii infection on health status of patients following an outbreak of Q fever.

To determine the health status of the patients of the Q fever outbreak in the Netherlands in 2007, one year after primary Q fever infection.

Infections in Stable Asthmatic Patients: Non Invasive Detection

The first aim of the study is to determine the prevalence of latent infections by non invasive assessment of induced sputum, exhaled breath condensate and nasal/throat swabs in stable asthmatic patients and controls. The second aim is to value…

Skin Autofluorescence and Capillary Permeability: Relevance of Measuring Advanced Glycation Endproducts in Critically Ill Patients

Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.

The course of viral respiratory tract infections in young children

1. To investigate the etiology and incidence of respiratory tract infection in children younger than 6 years of age.2. To investigate the course of respiratory tract infections in children younger than 6 years of age.3. To investigate the clinical…