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Safety and protective efficacy of BCG vaccination against controlled human malaria infection

The primary objective is to determine the safety and tolerability BCG vaccination followed by controlled human malaria infection; and to determine the protective efficacy BCG vaccination against a controlled human malaria infection.

Secondary Manifestations of Arterial Disease - Influence of Cardiovascular Prognosis and Treatment Effect Predictions on Patient and Physician Decision-Making: a Three-armed, Blinded, Randomized Controlled Trial

The primary objective is to compare differences between the communication strategies (personalized vs. standard, and personalized using iARR vs. personalized vs. CVD-free prognosis) on decisional certainty in patients with CVD at 1 month post-…

A two-part, single dose, randomized, single-blinded, placebo controlled, phase I study to assess the safety and pharmacokinetics of oral MT1980 in healthy volunteers when dosed in the fasted state

In this study we will investigate how safe the new compound MT1980 is and how well it is tolerated when it is used by healthy participants. We also investigate how quickly and to what extent MT1980 is absorbed, transported, and eliminated from the…

A study evaluating the pharmacokinetics, safety and tolerability of OP2113 administered intravenously in healthy volunteers and a marketed formulation administered orally

Primary objectives1. To evaluate the pharmacokinetic (PK) profile of the parent compound (anethole trithione, ATT) and its main metabolite (5-[4-hydroxyphenyl]-3H-1,2-dithiole-3-thione, ATX ) following administration of a range of doses of i.v.…