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The relationship between pain and cognitive functioning, of patients with neurodegenerative diseases such as Parkinson's disease, Multiple Sclerosis and Huntington's disease
Substudy: The relationship between pain, cognitive functioning, and motor activity in patients with multiple sclerosis

Various brain areas play a crucial role in both pain and cognition, supporting the existence of a close relationship between pain and cognition. Consequently, it is important to examine whether pain experience changes at the moment the patient shows…

Application of cultured autologous keratinocytes in combination with a meshed split skin autograft for burn wound healing

ObjectiveEvaluation of the application of cultured autologous keratinocytes in combination with a meshed split skin autograft to improve burn wound healing

The retro-orbital fibrobast: a key player in Graves* opthalmopathy and a target for therapy.

Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.

Genes and gene-function in bicuspid aortic valves

The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…

Investigating the genetic building blocks of emotion and behaviour in the general population

This study aims to identify the relationship between candidate genes such as for instance BDNF, 5-HTTLPR, DAOA, G72, DTNBP1, NRG1 and COMT with cognitive function and emotional- and behavioural traits.

Cortical activation during voluntary contraction in spinal cord injured subjects

In humans with SCI, we propose to use functional magnetic resonance imaging (fMRI) to: 1) examine the cortical areas that are activated during voluntary contractions, and 2) evaluate how cortical activation patterns change as a muscle is fatigued.…

An Exploratory Observational, Single-Centre Study in Patients with Disabling Chronic Obstructive Pulmonary Disease to Identify Biomarkers for *Systemic Disease*, Co-Morbidities, Increased Health Care Costs and Poor Prognosis. (CIROCO).

The main objective of the current study is to search for biomarkers, which will be investigated with their predictive value with respect to the course of COPD in lungfunction, exacerbations, health care use and mortality. The effects of the…

A Randomized, 4-Arm, Placebo-Controlled Phase 2 Trial of AMG 386 in Combination with Bevacizumab and Paclitaxel or AMG386 plus Paclitaxel as First-Line Therapy in Subjects with Her2-Negative, Metastatic or Locally Recurrent Breast Cancer.

To estimate the treatment effect as measured by progression free survival(PFS) of subjects receiving AMG 386 (at 2 doses) in combination with paclitaxel + bevacizumabrelative to paclitaxel + bevacizumab + placebo.

Evaluation of the potential of Real-Time 3-Dimensional echocardiography in the assessment of right ventricular function in patients with congenital heart disease: comparison of RT-3D echo with MRI.

The aim of this study is assessment of right ventricular function: a comparison between MRI and real-time 3-D echocardiography (RT 3-D echo). We have the following research questions: 1) Is assessment of right ventricular (RV) function with RT 3-D…

PENGUIN-trial: pancreatitis, endoscopic transgastric versus primary necrosectomy in patients with infected necrosis. A randomised controlled multicenter observer-blinded trial

To investigate if endoscopic transgastric necrosectomy will lead to a reduction ofthe per- and postoperative pro-inflammatory response, as compared to necrosectomy by laparotomy, in patients with infected (peri-)pancreatic necrosis.

A pilot study of immunorespons in children with Down syndrome after Respiratory Syncytial Virus (RSV) lower respiratory tract infections (LRTI)

The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.

An open, prospective, comparative clinical trial to evaluate the improvement of the colposcopist with the use of DySIS* compared to conventional colposcopy.

Primary:To validate the latest version of DySIS in discriminating high grade (HG) from low grade (LG) lesions and non neoplastic tissue as well as in selecting the most atypical site for biopsy sampling, through digital documentation and…

Implementation of a strategy of osteoporosis screening in patients over 50 years of age with a first fracture, with intensive treatment and follow-up by a nurse-practitioner to prevent recurrent fractures in those patients with diagnosed osteoporosis

Is it possible to improve routine detection and treatment of osteoporosis after an initial fracture?I) is it possible to increase the proportion of patients adequately screened and categorized as to the presence of osteoporosis from current practice…

Sodium Oxybate for the Treatment of Vigilance Impairment in Narcolepsy

Core:1. Quantify vigilance using a portable task battery three times daily during 7 days while subjects are outside the hospital 1.1 Comparing narcoleptic patients to controls 1.2 Comparing narcoleptic patients before and after treatment with sodium…

Evaluation of the Effectiveness of Psycho-Education for Stroke Patients in a Nursing Home and their Care-Givers

The aim of the current study is to investigate the effectiveness of the psycho-educational program started at nursing home Klevarie for stroke-patients and their caregivers in expanding their: knowledge about a stroke and its consequences;…

Validation of a repeated cardiopulmonary exercise test for the assessment of physical impairment in chronic fatigue syndrome.

We need objective and validated tests for the assessment of the severity of impairment in CFS/ME patients. In 2 areas these tests will be essential: for studies of the effect of interventions and for the assessment of disability.Hardly any research…

The reservecapacity of the peritoneum with the NO donor sodium nitroprusside during peritoneal dialysis

The objective is to analyze whether a difference in reservecapacity is present between short-term and long-term PD patients. In case the reservecapacity of the peritoneum is significantly lower in the long-term compared to short-term PD patients, a…

Prevention of neutrophil induced extracellular matrix damage following skin exposure to solar simulating radiation (SSR)

To investigate the effect of a sunscreen, a topical antioxidant and a topical corticosteroid on erythema, infiltrating neutrophils and oxidative stress following exposure of the skin to SSR.

Mucosal saturation measurements in patients suspected for chronic gastrointestinal ischemia

Evaluation of the diagnostic value of stomach and small bowel mucosal oxygen saturation measurements in patients suspected for chronic gastrointestinal ischemia.Determination of normal mucosal oxygen saturation values in patients without chronic…

Beta amyloid oligomers in the early diagnosis of AD and as marker for treatment response

The project has the following objectives:1. To investigate the diagnostic value of beta amyloid oligomers in CSF and plasma for AD in subjects with mild dementia. 2. To investigate whether beta amyloid oligomers in CSF and plasma can predict AD in…