53 results
Primary objective:* To investigate the consequences of (recurrent) hypoglycaemia on inflammatory responsesSecondary objectives:* To study the atherogenic consequences of (recurrent) hypoglycaemia* To study the molecular mechanisms involved in the…
Primary objective: To investigate the prevalence of bruxism and TMD in PD patients through objective measurements and to identify factors associated with a higher risk of developing these symptoms.Secondary objectives: - To investigate the salivary…
The main objective of this study is to identify prognostic, stratification, and/or outcome biomarkers for ASD. Prognostic marker refers to any objectively measurable test that helps to predict a child's likely developmental course; whether his…
To investigate which molecular mast cell phenotypes (as defined by the expressed genes and gene-networks) in bone marrow resident mast cells and their progenitors are associated with the presence or absence of ISM.
The main objective of this study is to compare the brainstem sound-evoked response of the subject groups with different hearing loss laterality and with/without tinnitus. These comparisons may let us know if the function of the human brainstem is…
Primary objective:1. To assess the effect of SXB treatment on cold-induced BAT volume and activity in narcolepsy type 1 patients.Secondary objectives:1. To assess the effect of SXB treatment on thermoneutral BAT volume and fat fraction, lipoprotein…
Aim of the study:To investigate the role of the CD200/CD200R axis on the responsiveness of whole blood, peripheral blood mononuclear cells (PBMCs) and neutrophils to a proinflammatory challenge in the immunoparalysed state in sepsis patients.…
Primary Objective: 1. To determine if and in what way the pelvic organ prolapse influences the sexual function and the self-image of the patient2. To compare the POP group and the control group on level of sexual function and (sexual) self-concept…
1) Assess whether individuals with ASD perform pantomimes with similar kinematics to typical individuals, and whether the typicality of their kinematics can be explained by motor impairment.2) Assess whether individuals with ASD are able to utilize…
The primary objective is to investigate the role of the hematopoeitic niche and mast cells in the bone marrow of MPN, and the effect of pharmacotherapy on these cells.
Objective: to investigate calcium containing crystal release in synovial fluid after exercise as drivers of synovitis in post-traumatic versus non-post traumatic osteoarthritis.
The main objective of our Center for Translational Pediatric Pulmonology (CTPP) is to establish models of bronchial epithelial function in children, by (1) epithelial organoid cultures derived from bronchial epithelial cells; (2) bronchial brushings…
The primary objective of the study is to examine muscle atrophy in fetuses with single or bilateral IPEV, in comparison to a normal population by measuring the circumference of the upper and lower legs by ultrasound examination. The length of the…
The objective is to identify non-invasive neuroimaging biomarkers and mechanisms characterizing different phenotypes of central disorders of hypersomnolence (narcolepsy type 1, narcolepsy type 2 and idiopathic hypersomnia) as compared to groups of…
Primary Objective: - To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors.Secondary Objective(s): - To identify specific patterns of brain…
Western Management strategies have been ineffective to modify the poor prognosis of GC. This proposal will focus on this specific challenge to *improve GC outcomes*, and will seek to gather evidence through international high-quality translational…
The main goal is to investigate if non-osmotic sodium storage in placental tissue, analogous with the skin, is harmful and associated with hypertensive disorders in pregnancy.
The primary objective is to assess the adaptive T cell response to VIT in HVA patients with underlying ISM (ISM+) after treatment induction (at thirteen weeks) and upon reaching maintenance dose, after seven months, in comparison to the baseline…
In this study, we aim to characterize the immunological defect in patients with CPA as compared to patients with chronic obstructive pulmonary disease (COPD) without CPA on a functional, genetic, transcriptional and metabolic level.
To identify new genetic defects in telomeropathies.