81 results
Primary Objective: • To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors. In other words, the aim is to investigate whether a more optimal…
The main goal is to test whether individuals with a panic disorder diagnosis differ in the level of fear generalization compared to matched controls. This would be a direct replication of the seminal study by Lissek et al. (2010).
Phenotypical and Pathophysiological Characterization of Patients with Alcohol-related Liver Disease.
The primary objective of the study is to identify, develop and validate non-invasive biomarkers for the assessment of alcohol use in patients with ALD. This by determining ethylglucuronide in hair, nail and urine in this population. By validating…
1. To evaluate if breastmilk of mothers who recovered from a proven COVID-19 infection contains antibodies (IgA) against SARS-CoV2.2. To evaluate if these antibodies are still present after pasteurization according the Holder method.
Study Objective 1To determine if the level and type of sport activity is associated with the development of hip deformities in the paediatric populationat 2 years. Intensive sport training and specialization has been implicated in the development of…
Identifying the genotype-phenotype-imaging correlates in GBA mutation carriers with and without Parkinson*s disease using functional and structural magnetic resonance imaging (MRI).
Primary objectives:1. To determine the gene frequencies of HLA-A, B, C, DR and DQ in patients with autoimmune encephalitis and compare this to the general Dutch population. 2. To determine genetic risk factors for the development of autoimmune…
The goal of this research project comprises two important components that are intricately related:1) To define the pathophysiological state of the peripheral motor pathway in patients with SMA and to determine the contribution of the constituting…
Objectives: 1) Assess neural and cognitive biomarkers (through eye-tracking, EEG/ERP and cognitive measures) in a community sample of infants at heightened non-familial risk for ASD and in age and gender matched low-risk controls. The HR group is…
To study the difference between the vaginal microbiome of fertile women with IBD and healthy controls, as determined by lactobacillus dominance.
To investigate the interrelatedness between clonal hematopoiesis of indeterminate potential (CHIP) and trained immunity.
The primary objective is to study the association between maternal TL and the risk of SB in offspring. The secondary objectives are to investigate the relation between maternal TL and obstetrical (pregnancy course and outcome), environmental risk…
The primary objective of this study is to investigate the sequence of segmental contributions in the cervical spine in the long-term follow-up of surgery for CDDD. Specifically, the motion of the cervical spine after ACD and ACDA will be analyzed…
Development of a laboratory assay
The objective is to examine how working memory functioning in children with ADHD and/or ASD as measured with the Lion game and the Monkey is influenced by context and to assess the diagnostic utility and ecological validity of the Lion and Monkey…
Determine the frequency, phenotype and function of disorder-related immune cells, or levels of immune molecules in skin and peripheral blood of patients with inflammatory skin diseases, during the active phase of disease prior to and/or at any time…
a) To evaluate whether PAPP-A2 and inhibin A could be used as biomarkers for preeclampsia and preeclampsia-related outcome in twin pregnancies. To achieve this objective, we will first assess:- Whether PAPP-A2 and inhibin A levels are increased in…
1. To investigate esophageal sensitivity to acid infusion and balloon distension in eosinophilic esophagitis patients with histological active disease and disease in remission, as compared to healthy controls 2. To investigate the difference in…
The aim of this study was to test these biomarkers of NO in glaucoma patients both with and without tinnitus. The objective was also to replicate findings from a previous study performed in Amsterdam, a collaboration between our research group and…
The overall goal of this study is to get an up-to-date data on the incidence, disease burden, and etiology of gastrointestinal infections in the general practitioner population. More specific goals:1. Determine the incidence of gastrointestinal…