Search for a trial

Urinary markers for fetal growth restriction: the role of gaseous vasoactive molecules.

Hypothesis: gaseous signaling molecules influence placental vasomotor activity to compensate for hypoxemia. Metabolites of these vasoactive molecules can be found in the blood and urine and can indicate whether this (compensatory) mechanism is used…

Cortical mechanisms of vestibular influence on hand choice.

The main objective is to investigate the preparatory process in left primary motor cortex in relation to hand choice during whole-body motion.

Beginning to unravel the cause of familial hypercholesterolemia of unknown origin (FH4)

To unravel the cause(s) of the FH phenotype in patients with no mutations in well-established lipid genes (LDLR, APOB, PCSK9).

Effect of administration of single dose Histidine-Tryptophane-Ketoglutarate (HTK) cardioplegia solution on serum sodium concentration, osmolarity and acid-base balance.

To analyse serum sodium concentration, serum osmolarity and arterial bloodgas at different times before and after administration of HTK solution, to get more insight of the impact of this solution on these biochemical parameters and to improve our…

Long-Term Multi-center Evaluation of E-Poly* and Regenerex* Cementless Acetabular Components: Clinical and Radiographic Outcomes

The purposes of this long-term mutli-center study are: - To compare the long-term (10-year) radiographic and clinical outcomes of new E-Poly* liner in primary total hip arthroplasty with the conventional ArcomXL® polyethylene liner.- To compare the…

Non-invasive assessment of lung remodeling in patients with idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) using [11C]-Nintedanib or [18F]-FLT PET imaging.

To investigate whether enhanced expression of growth factor receptors (FGF-R, PDGF-R and VEGF-R) and increasedvascular cell proliferation in the lung of IPF or PAH patients can be assessed using [11C]-Nintedanib or [18F]-FLTPET/CT imaging.

Long-term efficacy and safety of microwave ablation in the treatment of mild axillary hidradenitis suppurativa: a randomized intra-patient controlled trial

Primary objective: To prospectively evaluate the lesion (AN-)count, i.e. abscesses, inflammatory nodules, and draining sinuses, in the axilla treated with MWA compared to the untreated contralateral axilla after six months.Secondary objectives: - To…

Prevention of intimal injury during transradial coronary intervention

To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.

The effect of periodontitis on innate immune activation and vascular wall inflammation in relation with atherosclerosis

The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…

Intestinal production of Imidazole Propionate in healthy and obese subjects with or without DM2;
a pilot trial

To study the pharmacokinetics of non-reactive labelled histidine (L-HISTIDINE:HCL:H2O (D5, 98%; 15N3,98%) and the effect on intestinal imidazole propionate (IP)production in small intestine vs colon in healthy controls, metabolic syndrome and DM2…

Investigation of the reliability of a manual test according the rotation of the knee

Define the normal outcome and spread of the range of motion of the knee-rotationThe outcome of the manual rotationtest of the knee compared with a rotation-device. (reliability of the test)Define inter- and intra-tester reliability of the manual…

The effects of ceasing opioid, benzodiazepine, or Z-hypnotic drug use on measures of driving performance and postural balance.

The aim of this study is primarily to investigate the effects of a withdrawal intervention on measures of driving performance in a clinical population that uses benzodiazepines, Z-hypnotics, or opioid analgesics chronically. As a secondary objective…

Improvement of reproducibility during radiation treatment in Head and Neck cancer patients

Currently, a 5-point mask and a standard headrest is used in the H&N patients. By replacing the standard headrest foran individual headrest that includes both the head, neck and part of the shoulders, it is expected that the translationsand…

Zoom@SVDS/CADASIL: Zooming in at microvascular malfunction in Small Vessel Disease due to CADASIL with 7T MRI

Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.

CRP-POCT in suspected airway infected patients in the long-term care facility

The main objective is to investigate the additional value of CRP-POCT (C-reactive protein point-of-care-test) testing in patients suspected of airway infections in long-term care facilities.

Aortic Replacement using Individualised Regenerative Allografts: Bridging the Therapeutic Gap

The purpose of this investigation is to evaluate decellularized homograft for aortic valve replacement (ARISE AV) rates in comparison to current valve substitutes within a large prospective multicentre surveillance at 6 leading European Centres for…

Searching for Explanations for Cryptogenic Stroke in the
Young: Revealing the Etiology, Triggers, and Outcome

Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…

Determination of phenotypic and epigenetic *trained immunity* characteristics of hematopoietic stem and progenitor cells in patients with established atherosclerosis, a proof-of-principle study

To investigate whether long-term activation of the innate immune system, named *trained innate immunity*, occurs at the level of the bone marrow progenitor cells in patients with significant coronary artery disease and whether this correlates with…

Screening of coeliac disease in the Preventive Youth Health Care Centres in the Netherlands

The aim of our project is to perform a novel mass screening to detect CD in 12 months-4 years old children who visit the YHCCs in a well-described region in the Netherlands, to show that it is feasible, efficient, cost-effective and well accepted by…

Multiple Sclerosis Family Study - Study to investigate whether rare gene mutations cause Multiple Sclerosis (MS) in ten Dutch families with multiple MS patients

Our primary objective is to identify de novo/rare mutations causative of MS using WES in members of multi-incident families. Our secondary objective is to describe phenotypes per family using questionnaires and semi-structured interviews with family…