14 results
To examine the effect of BCG vaccination on the composition and function of the bone marrow.
The primary objective is to determine the safety and tolerability BCG vaccination followed by controlled human malaria infection; and to determine the protective efficacy BCG vaccination against a controlled human malaria infection.
This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…
The main objective of this study is to assess the ability of a wearable measurement system, the Hexoskin smart shirt, to detect and quantify dynamic hyperinflation. Secondary objectives are to determine the optimal measurement procedure and to…
1. Determine body composition of MD patients;2. Determine physical function of MD patients;3. Determine the association of body composition and physical function of MD patients.
Primary objectiveTo compare the effect on pulmonary vascular resistance (PVR) of an initial triple oral regimen (macitentan, tadalafil, selexipag) versus an initial dual oral regimen (macitentan, tadalafil, placebo) in newly diagnosed, treatment-…
The primary objective is to compare differences between the communication strategies (personalized vs. standard, and personalized using iARR vs. personalized vs. CVD-free prognosis) on decisional certainty in patients with CVD at 1 month post-…
To assess the long-term safety and tolerability of 35 mg and 70 mg RVT-101 in subjects with DLB
To determine ex vivo neutrophil functions following exposure to therapeutic antibodies targeting inhibitory receptors expressed by neutrophils from RSV bronchiolitis patients. A secondary aim is to study soluble inhibitory receptors (such as LAIR-1…
Develop and implement a new functional MRI protocol for function mapping in young children.
In this study we will compare the (cost-) effectiveness on depression of 25- versus 50-sessions of psychotherapy (SPSP or ST) within one year in patients with depression and comorbid personality disorders. In addition we will examine the personality…
To obtain sex-specific biomarkers, based on pathogenesis of microvascular disease, that improve the early diagnosis of diastolic dysfunction and HFPEF. These biomarkers come from innovative sources such as circulating endothelial cells,…
Objective: Since the inflammatory reaction plays an important role in wound healing problems and scar formation the main goal of this project is to unravel different inflammatory mechanisms involved. • Explore relationships between local and…
Primary questionAre changes in vigilance in type 1 and 2 narcolepsy, idiopathic hypersomnia and epilepsy with only nocturnal seizures reflected in differences in the responsiveness of the pupils to light as measured by pupillometry (PIPR) versus…