37 results
Primary goal:To provide an overview of long term effects (neurocognitive, behavioral and learning problems) in children with MTHI and to identify specific risk groups with a higher prevalence of more serious problems. This knowledge can contribute…
To gain insight into the biological pathways that are influenced by the CEEx30/31 mutations.
This pilot prospective cohort study is designed to provide feasibility data for a large global study that will critically evaluate the impact of sport activity and FAI development during the critical phase of hip maturation.Primary Feasibility…
The primary objective is to determine the effect of a 8-week inspiratory muscle training program on respiratory muscle function in nemaline myopathy patients. The secondary objective is to determine respiratory muscle function in nemaline myopathy…
The present study aims to examine if BA has a positive effect on the severity of depressive symptoms as measured by the PHQ-9 in adolescent depressive participants. In addition, several additional objectives are included (classification of the…
The primary objective of this study is to describe the intracardiac anatomy and hemodynamics of DILV patients without Fontan circulation using 4D MRI. Furthermore, the functional status and quality of life of these patients will be assessed and…
1. To examine whether the PI3K-AKT pathway is overly activated in children with Down syndrome compared to healthy age-matched controls. 2. To determine the rate of exhaustion and the apoptosis of lymphocytes in children with DS. 3. To determine the…
1) To investigate the effectiveness of Multi-family therapy (MFT) versus individual oriented treatment as usual (TAU) on end-of-treatment family functioning of veteran families, as reported by the veteran. TAU consists of supportive counselling or…
The primary objective is to evaluate the effect of the PAL-system on diabetes self-management determinants and behaviour and as a result on the health of children with T1DM. The PAL-System consist of a robot and a MyPAL-app, containing an avatar of…
Our primary objective is to compare children with FXS with children with non-syndromic ASD, a developmental delay (DD) and typically developing (TD) children on three domains: ASD severity, cognitive abilities and (neuro)biological characteristics.…
This is the first project in The Netherlands aimed at testing the acceptability, feasability and effectivity of an online intervention aimed at the psychosocial functioning of adolescents with a visible difference. The aim is to 1) test if the…
The overall aim of the study is to correlate the anatomical and functional anatomy of the larynx, as seen on MRI to various functional outcome measures in patients who underwent open airway surgery for LTS. The specific aims of this study are: 1) to…
The goal of the study is to examine whether optimal exposure is more effective than CBT as usual in youth with anxiety disorders. The secondary objective is to investigate whether decreases in harm expectancies are predictive of treatment outcome,…
Objective: The present protocol is nested in the TRACE study (CMO 2014-1349, NL50015.091.14 and in the linked TRACE-BIOME study, CMO 2015-1806, NL53630.091.15), and explores whether an ED, compared to healthy diet, affects the fronto-striatal and…
1.3. Study Design Rationale The ATLAS-PPX trial (ALN-AT3SC-009) is a multicenter, multinational, open-label Phase 3 switching study designed to demonstrate the efficacy and safety of fitusiran in patients with hemophilia A or B, with inhibitory…
Do neonatal critically ill children aged 9-16 years have problems with visuomotor integration? If yes, which aspects of the visuomotor integration are affected and require a possible intervention?
The primary purpose of this study is to determine how excessive parental criticism and lack of empathy affects the emotional and neural development during adolescence and whether there are bidirectional influences between parent-child interactions…
- To determine between-subject and within-subject variability of the study endpoints.- To determine the differences between subjects and healthy controls regarding the study endpoints.- To identify suitable endpoints for future clinical trials in…
General- To compare physical activity levels of pediatric patient subjects with healthy control subjects.- To compare mean heart rate and variation in heart rate during the day of patients and healthy controls.- To compare sleep duration of patients…
- To determine a mean recovery period for patients admitted with pneumonia, bronchiolitis, preschool wheezing and asthma by using data obtained during admission and via home-monitoring of a two week period following admission and control period and…