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Immunological and Genetic Risk factors for Cardiac Serious Adverse Events following Controlled Human Malaria Infections: a Case-Control study

To identify host risk factors through genetic and immunological screening that may be associated with the development of cardiac SAEs following CHMI. Identification of such factors may on the one hand allow at-risk individuals to be screened out…

Towards optimal management of Marfan Syndrome

The aim is to obtain sufficient data about aortic hemodynamics and motion in MFS patients in different disease stages (e.g. native aorta, after conventional surgery and after PEARS procedure) and while receiving different medical treatments, to…

PEERLESS study

The primary study objective is to compare the clinical outcomes of patients treated with the FlowTriever System versus Catheter-Directed Thrombolysis (CDT) for use in the treatment of acute intermediate-high-risk pulmonary embolism (PE).

DE-escalating ocRelizumAb In cLinical and radiological stable MS

To describe the efficacy and safety of a maintenance versus induction anti-CD20 treatment strategy in pwMS.

A randomized trial of ultrasound-facilitated, catheter-directed, thrombolysis versus anticoagulation for acute intermediate-high risk pulmonary embolism: The higher-risk pulmonary embolism thrombolysis study

The primary objective of the study is to assess whether ultrasound-facilitated, catheter-directed, thrombolysis and anticoagulation are associated with a significant reduction in the composite outcome of PE-related mortality, cardiorespiratory…

ORACLE: A long-term follow-up study to evaluate the safety and durability of GT005 in participants with geographic atrophy, secondary to age-related macular degeneration treated in a Gyroscope-sponsored antecedent study.

The overall objectives of the study are to evaluate the long-term safety and durability of GT005 in participants with GA secondary to AMD who have been treated in an antecedent study.